Neuroradiological differentiation of white matter lesions in patients with multiple sclerosis and Fabry disease

Table 1 Baseline characteristics

	Fabry disease n = 21	Multiple sclerosis n = 21	p values
Sex			0.76
Female	12 (57%)	13 (62%)
Male	9 (43%)	8 (38%)
Age median (IQR, range)	46 (27; 19–67)	45 (25; 19–61)	0.80
TIA or Stroke	2 (8.7%)	0	0.49
Cardiomyopathy	13 (65%)	0	< 0.001^‡
Chronic kidney disease	13 (65%)	0	< 0.001^‡
Enzyme replacement therapy	16 (76%)	NA
Lesion load			0.27
Singular lesions	17 (81%)	14 (67%)
Beginning confluence	2 (10%)	6 (28%)
Large confluent areas	2 (10%)	1 (5%)
MS type
RRMS	NA	13 (62%)
SPMS	NA	7 (33%)
PPMS	NA	1 (5%)
EDSS median (IQR; range)	NA	3.5 (3.3; 0–7)
CSF (pos. OCBs and/or intrathecal IG production)	NA	20 (95%)

Clinical features at the time of brain MR imaging. Lesion load was visually assessed and rating was based on the classification of Fazekas et al. [22] for white matter lesions but extended to all lesion locations. CSF cerebrospinal fluid, EDSS expanded disability status scale, IG immunoglobulin, IQR interquartile range, OCB oligoclonal bands, TIA transient ischemic attack, RRMS relapsing–remitting multiple sclerosis, SPMS secondary-progressive multiple sclerosis, PPMS primary-progressive multiple sclerosis
^‡Statistically significant

ISSN: 1750-1172