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Table 2 PedsQL summary (age 8–12 years; child reported)

From: Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency

 

Patient 8a

Patient 9a

Mean (SD)

PedsQL total score at baseline

48.9

57.6

53.3 (6.2)

Change in PedsQL total score at Week 52

28.3

3.3

15.8 (17.7)

Percent change in total PedsQL score at Week 52

57.8

5.7

31.7 (36.8)

P = 0.0311

PF

34.4

 − 9.4

12.5 (30.9)

PH

25.0

10.0

17.5 (10.6)

Body weight, percent change

 − 20.1

 − 2.4

 − 11.2 (12.5)

  1. PedsQL, Pediatric Quality of Life Inventory; PH, psychosocial health; PF, physical functioning; POMC, proopiomelanocortin; SD, standard deviation
  2. aPatient enrolled in POMC trial