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Table 1 Distribution of genetic variants in different group

From: Estimating the frequency of causal genetic variants in foetuses with congenital heart defects: a Chinese cohort study

CHD group n Chromosomal abnormalities
Aneuploidies Clinical significant CNVs Total
Isolated CHD 134 10 (7.5%) 18 (13.4%) 28 (20.9%)
Non-isolated CHD 66 13 (19.7%)* 8 (12.1%) 21 (31.8%)
 CHD plus structural anomalies 28 3(10.7%) 5(17.9%) 8(28.6%)
 CHD plus soft marker 22 5(22.7%)* 1(4.5%) 6(27.3%)
 CHD plus structural anomalies & soft marker 16 5(31.3%)* 2(12.5%) 7(43.8%)
Simple CHD 178 20(11.2%) 22(12.4%) 42(23.6%)
Complex CHD 22 3(13.6%) 4(18.2%) 7(31.8%)
  1. *Compared with isolated CHD, p < 0.05
  2. CHD, congenital heart disease; CNV, copy number variation;