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Table 6 Psychometric validation: test–retest intraclass correlations of the ctGD1-PROM (n = 23)

From: Development and validation of Gaucher disease type 1 (GD1)-specific patient-reported outcome measures (PROMs) for clinical monitoring and for clinical trials

Item Observations ICC 95% confidence interval
GD Education/job 22 0.509 0.118 0.763
GD Friends 23 0.682 0.384 0.851
GD Intimate 22 0.613 0.264 0.820
GD Hobbies leisure 23 0.757 0.508 0.889
GD Emotional burden 22 0.626 0.297 0.824
GD General-specific med 23 0.567 0.204 0.791
GD Concerns Gaucher 23 0.625 0.303 0.821
GD Current med. concerns 22 0.530 0.141 0.775
GD Dependent 22 0.500 0.107 0.757
GD Abdomen 22 0.974 0.939 0.989
GD Fatigued 22 0.816 0.606 0.919
GD Physical weakness 22 0.900 0.775 0.957
GD Bone pain 22 0.798 0.575 0.911
GD Depressed 22 0.482 0.075 0.749
GD Worried 22 0.512 0.123 0.764
GD Future 22 0.843 0.598 0.937
GD Satisfied 23 0.399 0.014 0.693
Average   0.893 0.750 0.954
  1. ctGD1-PROM clinical trials (17-item) Gaucher disease type 1-specific patient-reported outcome measure questionnaire, GD Gaucher disease, ICC intraclass correlation coefficient