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Table 5 Psychometric validation: internal consistency reliability statistics for the ctGD1-PROM

From: Development and validation of Gaucher disease type 1 (GD1)-specific patient-reported outcome measures (PROMs) for clinical monitoring and for clinical trials

Item

Item-test correlation

Item-rest correlation

Inter-item correlation

Cronbach’s alpha

GD Education/job

0.658

0.605

0.434

0.925

GD Friends

0.783

0.745

0.422

0.921

GD Intimate

0.576

0.514

0.442

0.927

GD Hobbies leisure

0.741

0.696

0.426

0.922

GD Emotional burden

0.848

0.821

0.415

0.919

GD General-specific med

0.356

0.276

0.464

0.933

GD Concerns Gaucher

0.208

0.118

0.476

0.936

GD Current med. concerns

0.364

0.286

0.463

0.932

GD Dependent

0.594

0.533

0.439

0.926

GD Abdomen

0.616

0.553

0.438

0.926

GD Fatigued

0.802

0.767

0.420

0.921

GD Physical weakness

0.868

0.844

0.413

0.919

GD Bone pain

0.868

0.843

0.413

0.919

GD Depressed

0.834

0.805

0.417

0.920

GD Worried

0.870

0.846

0.413

0.919

GD Future

0.792

0.757

0.421

0.921

GD Satisfied

0.826

0.795

0.417

0.920

Overall

  

0.431

0.928

  1. ctGD1-PROM clinical trials (17-item) Gaucher disease type 1-specific patient-reported outcome measure questionnaire, GD Gaucher disease