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Table 4 Psychometric validation: correlations between the ctGD1-PROM items and SF-36 PCS and MCS scores

From: Development and validation of Gaucher disease type 1 (GD1)-specific patient-reported outcome measures (PROMs) for clinical monitoring and for clinical trials

Items Correlation with PCS Correlation with MCS
Coefficient (p < 0.05) (p < 0.1) Coefficient (p < 0.05) (p < 0.1)
GD Education/job 0.739 ✓ ✓ 0.792 ✓ ✓
GD Friends 0.594 ✓ ✓ 0.722 ✓ ✓
GD Intimate 0.633 ✓ ✓ 0.702 ✓ ✓
GD Hobbies leisure 0.684 ✓ ✓ 0.724 ✓ ✓
GD Emotional burden 0.616 ✓ ✓ 0.742 ✓ ✓
GD General-specific med 0.205 x x 0.383 ✓ ✓
GD Concerns Gaucher 0.139 x x 0.023 x x
GD Current med. concerns 0.172 x x 0.358 ✓ ✓
GD Dependent 0.715 ✓ ✓ 0.274 x ✓
GD Abdomen 0.478 ✓ ✓ 0.415 ✓ ✓
GD Fatigued 0.680 ✓ ✓ 0.609 ✓ ✓
GD Physical weakness 0.750 ✓ ✓ 0.615 ✓ ✓
GD Bone pain 0.787 ✓ ✓ 0.594 ✓ ✓
GD Depressed 0.514 ✓ ✓ 0.808 ✓ ✓
GD Worried 0.566 ✓ ✓ 0.819 ✓ ✓
GD Future 0.567 ✓ ✓ 0.647 ✓ ✓
GD Satisfied 0.656 ✓ ✓ 0.691 ✓ ✓
  1. GD Gaucher disease, MCS mental component score, PCS physical component score, SF-36 36-item Short Form Health Survey
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172