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Table 7 Factor IX unit costs (2021 unit costs unless noted otherwise)a

From: Clinical, humanistic, and economic burden of severe haemophilia B in adults receiving factor IX prophylaxis: findings from the CHESS II real-world burden of illness study in Europe

FIX unit cost (EUR) UK France Germany Italy Spain
Alprolix® 0.96 (2018)a 1.47 1.38 1.24 (2020)a
Idelvion® 2.32 1.97 2.20 2.30 (2020)a
Refixia® 2.71 1.70
BeneFIX® 0.67a 0.65 (2011)a 0.87 0.73a 0.46
Rixubis® 0.67 0.65 (2017)a 0.77 0.69 0.46
AlphaNine® 0.43 (2018)a 0.72 0.41a
  1. Unit costs were from the Pharmaceutical Pricing and Reimbursement Information (https://ppri.goeg.at/medicine_price_data)
  2. aOther country-specific sources were as follows: for the United Kingdom, the British National Formulary (https://www.nice.org.uk/) and Branded Health Service Medicines Regulations 2018 (https://www.legislation.gov.uk/uksi/2018/345/contents/made); France, Modalités de prise en charge d’Aprolix (https://www.hematoalaune.fr/rubriques/vie-des-medicaments/modalites-de-prise-charge-dalprolix-eftrenonacog-alpha/#), Légifrance (https://www.legifrance.gouv.fr); Italy, Starbene (www.starbene.it); Spain, La Comisión Interministerial modifica el precio de 50 medicamentos (https://www.actasanitaria.com/la-comision-interministerial-modifica-el-precio-de-50-medicamentos/#:~:text=En%20cuanto%20al%20Alprolix%2C%20con,€%20para%20el%203000%20Ul)