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Table 7 Factor IX unit costs (2021 unit costs unless noted otherwise)a

From: Clinical, humanistic, and economic burden of severe haemophilia B in adults receiving factor IX prophylaxis: findings from the CHESS II real-world burden of illness study in Europe

FIX unit cost (EUR)

UK

France

Germany

Italy

Spain

Alprolix®

0.96 (2018)a

1.47

1.38

1.24 (2020)a

Idelvion®

2.32

1.97

2.20

2.30 (2020)a

Refixia®

2.71

1.70

BeneFIX®

0.67a

0.65 (2011)a

0.87

0.73a

0.46

Rixubis®

0.67

0.65 (2017)a

0.77

0.69

0.46

AlphaNine®

0.43 (2018)a

0.72

0.41a

  1. Unit costs were from the Pharmaceutical Pricing and Reimbursement Information (https://ppri.goeg.at/medicine_price_data)
  2. aOther country-specific sources were as follows: for the United Kingdom, the British National Formulary (https://www.nice.org.uk/) and Branded Health Service Medicines Regulations 2018 (https://www.legislation.gov.uk/uksi/2018/345/contents/made); France, Modalités de prise en charge d’Aprolix (https://www.hematoalaune.fr/rubriques/vie-des-medicaments/modalites-de-prise-charge-dalprolix-eftrenonacog-alpha/#), Légifrance (https://www.legifrance.gouv.fr); Italy, Starbene (www.starbene.it); Spain, La Comisión Interministerial modifica el precio de 50 medicamentos (https://www.actasanitaria.com/la-comision-interministerial-modifica-el-precio-de-50-medicamentos/#:~:text=En%20cuanto%20al%20Alprolix%2C%20con,€%20para%20el%203000%20Ul)