Fig. 3
Estimated effects of rare disease legislation on SSc scientific output. Effects of rare disease legislation on ln of SSc publications are presented as regression coefficients (95% CI) separately for all countries (blue), HICs (red) and MICs (green). Legislation dummy variables, t−5 to t+10 are equal to one in only one year per country with rare disease legislation. t0 refers to the year after legislation implementation. Dummy variables prior t0 (t−5 to t−1) were used to test for parallel trend, and those after t0 (t+1 to t+10) showed the dynamics of legislation effect over time. Country and year fixed effects as well as country-level covariates were controlled. HICs high-income countries, MICs middle-income countries, SSc systemic sclerosis