Fig. 1From: Impact of the COVID-19 pandemic on access to the cerliponase alfa managed access agreement in England for CLN2 treatmentTime course of restrictions implemented during the COVID-19 pandemic in England [11]. ‘Support bubbles’ allowed two households to mix exclusively, without social distancing, under certain circumstances, including families with a child under 5 years of age requiring continuous care and lone parent families [14]. Under the tier system, restrictions in individual cities and regions were determined according to local case ratesBack to article page