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Fig. 8 | Orphanet Journal of Rare Diseases

Fig. 8

From: Growth in achondroplasia including stature, weight, weight-for-height and head circumference from CLARITY: achondroplasia natural history study—a multi-center retrospective cohort study of achondroplasia in the US

Fig. 8

Head circumference-for-age from birth through 5 years for children with achondroplasia, 5th, 25th, 50th, 75th and 95th percentiles. Male curve (top) derived from 3449 data points from 534 subjects and female curve (bottom) derived from 3012 data points from 489 subjects. These figures include data points from subjects who underwent shunt placement and cervicomedullary decompression (CMD) (from before and after the procedures). There was no difference in the male or female head circumference-for-age curves when the data points from these subjects were excluded. For males, there were 361 data points from 49 subjects who had a shunt (196 data points after the surgery) and 825 data points from 116 subjects who had CMD (462 data points after the surgery). For females, there were 197 data points from 99 subjects (116 data points after the surgery) and 757 data points from 122 subjects who had CMD (374 data points after the surgery). This figures include data points from subjects who underwent shunt placement and CMD (from before and after the procedures). There was no difference in the male or female head circumference-for-age curve when the data points from these subjects were excluded. For males, there were 361 data points from 49 subjects who had a shunt (196 data points after the surgery) and 825 data points from 116 subjects who had CMD (462 data points after the surgery). For females, there were 197 data points from 99 subjects (116 data points after the surgery) and 757 data points from 122 subjects who had CMD (374 data points after the surgery)

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