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Table 2 Comparisons of clinical and biological characteristics (a) and lymphocyte parameters (b) between HHT patients with or without history of severe infection

From: Altered expressions of CXCR4 and CD26 on T-helper lymphocytes in hereditary hemorrhagic telangiectasia

  HHT with HSI HHT without HSI p
(a) Clinical and biological characteristics
 Age (mean, SD) 60.0 (10.3) 60.4 (10.5) 0.91
 Sex (male, %) 13 (72%) 13(72%) 1
 Mutation (n, %)1
  - ENG 11 (61%) 7 (39%) 0.49
  - ACVRL1 7 (39%) 9 (50%)  
 Epistaxis frequency (n, %)
  - Daily 6 (34%) 7 (39%) 0.56
  - Weekly 8 (44%) 5 (28%)  
  - Monthly or more rarely 4 (22%) 6 (34%)  
   Visible telangiectases (median, min–max) 58 (0–242) 90 (0–200) 0.39
 Arteriovenous malformations (n, %2)
  - Lung3 9 (50%) 3 (18%) 0.044
  - Digestive tract 7 (63%) 12 (80%) 0.35
  - Liver 8 (44%) 7 (44%) 0.97
  - Brain 5 (29%) 1 (14%) 0.78
 Treatment (n, %)
  - IV iron or blood transfusion (at least 5) 8 (44%) 12 (67%) 0.14
  - Tranexamic acid 2 (11%) 4 (22%) 0.37
  - Bevacizumab 1 (6%) 3 (17%) 0.29
 Basic biological parameters (median, min–max):
  Hemoglobin (g/l) 135 (80–188) 126 (78–157) 0.16
  Platelets (G/l) 245 (178–388) 262 (236–488) 0.15
  Leucocytes (G/l) 5.44 (3.00–8.92) 5.23 (3.02–10.23) 0.95
  Neutrophils (G/l) 4.06 (1.73–7.65) 4.02 (1.94–8.19) 0.67
  Lymphocytes (G/l) 0.92 (0.3–2.4) 1.02 (0.4–2.34) 0.89
  C reactive protein (mg/l) 2.63 (0.2–8.4) 1.85 (0.2–7.3) 0.63
  Ferritin (ng/ml) 76 (9–158) 57 (7–221) 0.43
  Creatinine clearance (MDRD, ml/min) 85 (36–107) 86.5 (42–140) 0.52
  Immunoglobulin G (g/l) 8,73 (2.7–16.8) 9.16 (3.16–16.9) 0.87
  Immunoglobulin A (g/l) 2.10 (1.04–4.3) 2.23 (1.07–4.06) 0.64
  Immunoglobulin M (g/l) 0.69 (0.36–1.79) 0.72 (0.19–1.9) 0.97
(b) Lymphocyte parameters (median, min–max)
 T lymphocytes (cells/mm3) 841 (219–2116) 829 (214–1831) 0.44
 T-helper lymphocytes (cells/mm3) 517 (96–1499) 550 (123–1061) 0.83
 T-cytotoxic lymphocytes (cells/mm3) 339 (90–848) 187 (51–1110) 0.12
 NK lymphocytes (cells/mm3) 211 (12–989) 170 (55–946) 0.64
 Naive T-helper lymphocytes (cells/mm3) 273 (8–978) 201 (14–630) 0.55
 Memory T-helper lymphocytes (cells/mm3) 236 (79–519) 280 (109–798) 0.60
 Activated T-helper lymphocytes (cells/mm3) 59 (19–151) 58 (30–215) 0.78
 CXCR4 MFI on T lymphocytes 3,87 (2.17–18.36) 3.74 (2.20–14.30) 0.80
 CXCR4 MFI on T-helper lymphocytes 4.80 (2.91–14.00) 4.17 (2.40–8.20) 0.48
 CXCR4 MFI on Naive T-helper lymphocytes 9.65 (4.48–35.00) 7.01 (3.34–14.20) 0.03
 CXCR4 MFI on memory T-helper lymphocytes 3.06 (2.28–9.79) 3.33 (1.91–6.00) 0.64
 CXCR4 MFI on activated T-helper lymphocytes 2.40 (1.71–8.15) 2.49 (1.63–4.00) 0.97
 CD26 MFI on T lymphocytes 2.71 (1.41–5.13) 2.90 (2.21–6.54) 0.13
 CD26 MFI on T-helper lymphocytes 3.01 (1.72–5.75) 3.26 (2.17–6.92) 0.19
 CD26 MFI on naive T-helper lymphocytes 4.59 (1.65–9.33) 5.73 (4.17–14.1) 0.03
 CD26 MFI on memory T-helper lymphocytes 2.27 (1.58–3.48) 2.58 (2.00–5.08) 0.09
 CD26 MFI on activated T-helper lymphocytes 1.63 (1.32–2.95) 1.57 (1.13–2.77) 0.29
 CXCR4/CD26 ratio on T lymphocytes 1.63 (0.52–5.45) 1.32 (0.45–4.38) 0.04
 CXCR4/CD26 ratio on T-helper lymphocytes 1.58 (0.86–3.41) 1.37 (0.62–2.91) 0.01
 CXCR4/CD26 ratio on naive T-helper lymphocytes 2.34 (0.87–5.68) 1.32 (0.51–3.01) 0.0002
 CXCR4/CD26 ratio on memory T-helper lymphocytes 1.38 (0.79–2.82) 1.39 (0.71–2.50) 0.25
 CXCR4/CD26 ratio on activated T-helper lymphocytes 1.70 (0.70–2.96) 1.63 (0.99–2.65) 0.93
  1. Statistically significant parameters are in bold
  2. n: Number, HSI: History of severe infection, MFI: Mean fluorescence intensity
  3. 1No mutation identified for 2 patients, both in the HHT without HSI group
  4. 2% of patients with a screening performed for the specified organ
  5. 3Only those large enough to be considered for treatment (diameter of the feeding artery > 3 mm)