Fig. 3

Influence of main HHT characteristics on T-helper count and their CXCR4 and CD26 surface expressions. Among the 36 subjects of the HHT group, comparisons of the T-helper count (a), the CXCR4 MFI ratio (b) and the CD26 MFI ratio (c) according to sex (male: 26, female: 10), mutations (ENG: 18, ACVRL1: 16), frequency of epistaxis (daily: 13, weekly: 13, month or less: 10), pulmonary AVM (with: 12, without: 23), digestive AVM (with: 19, without: 7), hepatic AVM (with: 15, without: 19), IV iron or transfusion (with: 20, without: 16). Correlations between T-helper count, CXCR4 expression, CD26 expression and age (d), number of telangiectases per patient (e), hemoglobin (f), ferritin (g). MFI: mean fluorescence intensity, Ep.: epistaxis, pAVM: pulmonary arteriovenous malformation, dAVM: digestive arteriovenous malformation, hAVM: hepatic arteriovenous malformation. Results are presented in bar charts with median and interquartile ranges (for comparisons) or individual values with Spearman r coefficient (for correlations). Comparisons between groups were performed using the Kruskal–Wallis or the Mann–Whitney U-test. Correlations between variables were performed using the Spearman’s rank test. P-values are shown