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Table 3 Cases of primary cervical GTN in a comprehensive literature review

From: Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

Case Reference Age Primary diagnosis Primary treatment β-hCG Complementary surgery Chemotherapy Follow-up (month)
1 Fu et al. [2] 46 Abortion Curettage 20,000 Hysterectomy Yes CR (17)
2   21 GTN Chemotherapy 5344 Hysterectomy Yes CR (16)
3   35 Abortion Curettage 4000 Hysterectomy Yes CR (14)
4   30 Abortion Curettage 2764 Hysterectomy Yes CR (6)
5 Baykal et al. [3] 54 Cervical cancer Cervical biopsy*, RH + BSO + BLN 45,000 No Yes NA
6 Ben et al. [4] 35 Cervical myoma Curettage NA Hysterectomy Yes NA
7 Sorbi et al. [5] 30 CSP Hysterectomy 60,000 No Yes NA
8 Lee et al. [6] 29 Cervical pregnancy MTX + Hysterectomy 180,580 No Yes NA
9 Mitrovic et al. [7] 35 NA Hysterectomy 13 No No NA
10 Herts et al. [8] 47 Cervical pregnancy Hysterectomy 109,870 No Yes NA
11 Kairi-Vassilatou et al. [9] 43 Ectopic pregnancy MTX + Curettage 7485 Hysterectomy Yes NA
12 Ben-Chetrit et al. [10] 33 Cervical cancer Cervical biopsy*, Cervical conization 32 No Yes CR (12)
13 Frati et al. [11] 32 Cervical cancer Cervical biopsy 30,750 No Yes NA
14 Yahata et al. [12] 38 Cervical polyp Cervical biopsy 12,800 Hysterectomy Yes CR (14)
15 Chandacham et al. [13] 33 Cervical cancer Cervical biopsy 45,724 No Yes CR (33)
16 Wang et al. [14] 27 NA Cervical biopsy 1900 Hysterectomy Yes CR (8)
17 Tsai et al. [15] 46 GTN Hysterectomy 162,550 No Yes NA
18   43 Cervical cancer Hysterectomy NA No Yes NA
19   29 GTN Hysterectomy NA No Yes NA
20 Park et al. [16] 31 NA Cesarean section + tumor resection NA Hysterectomy Yes NA
21 Tsukamoto et al. [17] 42 Cervical cancer Cervical biopsy* 8000 Hysterectomy Yes NA
22 Tripathi et al. [18] 28 NA Curettage 54,000 Hysterectomy Yes CR (10)
23 Karaman et al. [19] 36 Ectopic pregnancy MTX + Cervical biopsy 5374 No Yes NA
24 Phippen et al. [20] 40 Cervical cancer Cervical biopsy* Cervical conization 20 Hysterectomy No NA
25 Wang et al. [21] 36 Cervical pregnancy Cervical pregnancy 149,100 No Yes NA
26 Roopnarinesingh et al. [22] 25 Ectopic pregnancy Laparoscopic exploration + cervical biopsy +curettage 4580 No Yes Relapse (6)
27 Zwischenberger et al. [23] 38 Cervical cancer Cervical biopsy 13 Hysterectomy No NA
  1. BLN bilateral pelvic-paraaortic lymph node dissection, BS bilateral salphingoopherectomy, CR complete remission, CSP cesarean section pregnancy, GTN gestational trophoblastic neoplasia, MTX methotrexate, NA not available, RH radical hysterectomy; *Pathology originally showed squamous cervical cancer