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Table 5 Clinicopathological features of ENKTL of different primary sites

From: Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series

Characteristics Breast*, n (%) Nasal, n (%) [23] GI tract, n (%) [24] Skin, n (%) [25] Testis, n (%) [14] Larynx, n (%) [13]
Number of cases 7 92 55 16 21 31
Median age (range) (year) 40 (20–54) 52 (21–89) 39 (14–75) 32 (16–72) 44 (21–79) 50 (13–77)
B symptoms 5 (100) 36 (39) 19 (35) 11 (69) 7 (33) 10 (32)
Ulceration 0 (0) NR 55 (100) 7 (44) NR 12 (39)
Concomitant diseases 5 (100) NR NR NR NR NR
Pleomorphic 5 (83) NR 42 (76) 13 (81) NR 8 (26)
Number of CD30 + cases 4 (67) 36 (39) 13 (41) 2 (15) 5 (31) NR
Median CD30 expression, % (range) 62.5 (50–80) NR NR NR NR NR
Median Ki-67 index, % (range) 80 (70–95) NR 70 (50–90) 60 (NR) 80 (50–90) 60 (30–80)
TR gene rearrangement (monoclonal/polyclonal) 3 (60) 35 (38) 9 (53) 0 (0) NR 1 (17)
Median survival (range) (month) 5 (1–9) 19.2 (NR) 14 (1–56) 7 (2–20) 15.3 (0.5–87) 9 (1–104)
  1. *Including primary cases from the current study and the literature review in Additional file 1: Table S1
  2. NR, not report; TR, T-cell receptor; n, number