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Table 4 Clinical features of ENKTL-Breast cases acquired from the present study and literature review

From: Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series

Characteristics Present study Literature [6,7,8,9,10,11] Total
Number of cases 8 (P: 3; S: 5) 7 (P: 4; S: 3) 15 (P: 7; S:8)
Median age (range) (year) 46 (26–63) 38 (20–47) 41 (20–63)
Origin (Asian/non-Asian) 8/0 1/3 9/3
Initial presented with breast mass (yes/no) 8/0 6/1 14/1
B symptoms (yes/no) 7/1 3/1 10/2
Ann Arbor stage (I/II vs III/IV) P: 3/0; S: 0/4 P: 2/0; S: 0/3 P: 5/0; S: 0/7
Immunophenotype CD56 (positive/negative) P: 2/1; S: 4/1 P: 2/0; S: 2/1 P: 4/1; S: 6/2
EBER (positive/negative) 8/0 6/1 14/1
TR gene rearrangement (monoclonal/polyclonal) P: 2/0; S: 1/4 P: 1/2; S: 0/1 P: 3/2; S: 1/5
Concomitant diseases (yes/no) P: 2/0; S: 1/4 P: 3/0; S: 0/3 P: 5/0; S: 1/7
Outcome(died/alive) 6/0 3/1 9/1
Median survival (range) (month) 6 (2–11) 5 (1–18) 5 (1–18)
  1. NA, not available; P, primary cases; S, secondary cases, mo, months; EBER, EBV-encoded small RNAs; TR, T-cell receptor