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Table 1 Chromosomal regions with affected or candidate genes contributing to non-syndromic HGF

From: Clinics and genetic background of hereditary gingival fibromatosis

Chromosomal region/gene locus

Affected# or candidate## gene

Gene/locus MIM number

Disease type

Phenotype MIM number

Inheritance

References

2p21-p22

(D2S1788, D2S441)

GINGF, GINGF1, GGF1

SOS-1#

182530

Hereditary gingival fibromatosis

type 1 (HGF1)

135300

AD

[6, 8, 12, 65]

2p16-p13

(D2S1788, D2S2298)

GINGF

Hereditary gingival fibromatosis type 1 (HGF1)

135300

AD, AR

[64, 65]

5q13-q22

(D5S1491, D5S1453)

GINGF2, GGF2

CAMK4##

114080

Hereditary gingival fibromatosis

type 2 (HGF2)

605544

AD

[9, 66, 67]

2p23.3-p22.3

(D2S2221, D2S1788) GINGF3, GGF3

Hereditary gingival fibromatosis

type 3 (HGF3)

609955

AD

[7, 68]

11p15

(D11S1984- D11S1338)

GINGF4, GGF4

Hereditary gingival fibromatosis

type 4 (HGF4)

611010

MI

[10, 69]

4q12

GINGF5, GGF5

REST#

600571

Hereditary gingival fibromatosis

type 5 (HGF5)

617626

AD

[11, 70]

  1. O(MIM), Online Mendelian Inheritance in Man; AD, autosomal dominant; AR, autosomal recessive; MI, maternal inheritance; CAMK4, calcium/calmodulin-dependent protein kinase IV; SOS-1, Son-of-Sevenless-1; REST, RE1-silencing transcription factor
  2. # affected gene, ## candidate gene contributing to HGF