Alterations in brain morphology by MRI in adults with neurofibromatosis 1

Table 4 Correlation values and p values of ocular globe measurements with clinical and neuropsychometric assessments in adults with NF1

	Clin. sev	Neuro. sev	ADD/ADHD	IQ	ACS	PC1	PC2	PC3	PC4	PC5
	Correlation matrix
Clin. sev		0.23	− 0.21	− 0.21	− 0.21	− 0.36	0.01	0.04	− 0.40	− 0.20
Neuro. sev			0.49	− 0.34	− 0.13	− 0.25	0.20	− 0.08	0.23	0.11
ADD/ADHD				0.04	− 0.03	0.13	0.36	− 0.18	0.10	0.26
IQ					0.16	0.50	− 0.11	− 0.01	− 0.02	− 0.36
ACS						− 0.10	− 0.18	− 0.07	0.09	0.01
PC1							0.12	0.06	0.08	− 0.05
PC2								0.06	− 0.04	0.04
PC3									− 0.05	0.04
PC4										0.00

Top five corpus callosum PCs are correlated to neuropsychometric measurements (clinical severity, n = 70; clinical neurological severity, n = 70; clinical ADD/ADHD diagnosis, n = 50; IQ, n = 61; and Attention Comparison Score, n = 68). The correlation matrix combines the Pearson correlation and Spearman correlation (italicized) results. Abbreviations used in the table: Clin. Sev. = clinical NF1 severity, Neuro. Sev. = clinical neurological severity, ADD/ADHD = clinical Attention deficit hyperactivity disorder severity, IQ = intelligence quotient, ACS = Attention Comparison Score, and PC = principal component

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