Alterations in brain morphology by MRI in adults with neurofibromatosis 1

Table 2 Correlation values and p values of corpus callosum measurements with clinical and neuropsychometric assessments in adults with NF1

	Neuro. sev	ADD/ADHD	IQ	ACS	PC1	PC2	PC3
Clin. sev	0.14	− 0.49	− 0.29	− 0.17	0.38	− 0.05	− 0.02
Neuro. sev		0.55	0.20	− 0.41	0.19	− 0.05	0.17
ADD/ADHD			0.26	− 0.17	0.01	− 0.20	− 0.06
IQ				0.10	− 0.01	− 0.41	0.33
ACS					− 0.22	0.23	0.08
PC1						− 0.20	− 0.03
PC2							− 0.09

Top three corpus callosum PCs are correlated to neuropsychometric measurements (clinical severity, n = 70; clinical neurological severity, n = 70; clinical ADD/ADHD diagnosis, n = 50; IQ, n = 61; and Attention Comparison Score, n = 68). The correlation matrix combines the Pearson correlation and Spearman correlation (italicized) results. Abbreviations used in the table: Clin. Sev. = clinical NF1 severity, Neuro. Sev. = clinical neurological severity, ADD/ADHD = clinical Attention deficit hyperactivity disorder severity, IQ = intelligence quotient, ACS = Attention Comparison Score, and PC = principal component

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