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Table 2 VOC prevalence distribution studies

From: A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease

Study identifier Country N Mean age VOC definition Distribution of VOC, %
Adekile et al. [ 53] Kuwait 396 19.2 Hospitalization 0/year: 3.3
      1/year: 54.8
      2–3/year: 13.2
      > 3/year: 18.9
Aloni et al. [54] Democratic Republic of Congo 168 10 Hospitalization > 48 h 0/year: 3.6
      1–3/year: 51.8
      > 3/year: 44.6
Andemariam et al. [20] U.S 384 30.1 Self-reported (patient survey; hospitalization, ED, managed at home) 0/year: 4
      1–4/year: 38
      ≥ 5/year: 59
Bailey et al. [14] England 15,076 30a Healthcare visit (OP, IP, or ED) ≥ 3/year: 4
Dave et al. [47] India 404 19 Healthcare visit (OP or IP) to care system 0/year: 11.9
      1/year: 15.6
      2/year: 22.8
      ≥ 3/year: 49.8
Delicou et al. [23] Greece 254 NR Healthcare visit (OP, IP, or ED) 0/year: 25.3
      1–5/year: 50.6
      5–10/year: 8.3
      > 10/year: 15.8
James et al. [19] Multiple 1513 24.1 Self-reported (patient survey; hospitalization, ED, managed at home) 0/year: 8
      1–4/year: 51
      ≥ 5/year: 40
Latremouille-Viau et al. [49] U.S 18,287b 28.5 Healthcare visit (OP, IP, or ED); Medicaid and Medicare claims 0/year: 36.1
      1/year: 17
      ≥ 2/year: 46.8
   15,431c 48.2   0/year: 44.9
      1/year: 11.4
      ≥ 2/year: 43.7
Rizio et al. [13] U.S 303 34.4 Self-reported (ASCQ-Me) 0/year: 8.9
      1/year: 9.6
      2/year: 14.5
      3/year: 19.8
      ≥ 4/year: 47.2
Shah et al. [22] U.S 8521 32.9 Healthcare visit (OP, IP, or ED); Medicaid claims 0/year: 52.3
      1/year: 14.7
      2/year: 6.7
      3/year: 4.6
      4/year: 3.7
      5/year: 2.7
      6/year: 2
      7/year: 1.5
      8/year: 1.4
      9/year: 1.4
      > 10/year: 9.2
van Tuijn et al. [55] Netherlands 95 37a Hospitalization 0/year: 23
      0–1/year: 43
      > 1/year: 16
  1. ASCQ-Me adult sickle cell quality of life measurement information system, ED emergency department, IP inpatient, NR not reported, OP outpatient, VOC vaso-occlusive crisis
  2. aMedian reported
  3. bMedicaid claims study arm
  4. cMedicare claims study arm