Biological implication | Gene symbol | Gene name | Control mean counts | MRS mean counts | Fold change | q-value |
---|---|---|---|---|---|---|
Evading apoptosis | BAD | BCL2 associated agonist of cell death | 826.17 | 116.74 | − 2.82 | 5.74e−05 |
BBC3 | BCL2 binding component 3 | 1275.40 | 66.71 | − 4.26 | 5.98e−06 | |
EGF | Epidermal growth factor | 62.50 | 700.46 | 3.49 | 2.01e−04 | |
FGFR2 | Fibroblast growth factor receptor 2 | 85.98 | 950.63 | 3.47 | 4.66e−03 | |
FLT3LG | fms related tyrosine kinase 3 ligand | 92.37 | 0 | − 4.90 | 4.48e−02 | |
HMOX1 | heme oxygenase 1 | 3398.05 | 733.82 | − 2.21 | 1.22e−03 | |
HRAS | HRas proto− oncogene, GTPase | 460.16 | 83.39 | − 2.46 | 2.96e−03 | |
IFNAR2 | Interferon alpha and beta receptor subunit 2 | 2464.19 | 83.39 | − 4.89 | 6.69e−11 | |
IGF1R | Insulin like growth factor 1 receptor | 2771.65 | 11591.01 | 2.06 | 1.07e−03 | |
IL12RB1 | Interleukin 12 receptor subunit beta 1 | 2509.33 | 617.08 | − 2.02 | 1.76e−05 | |
IL13RA1 | Interleukin 13 receptor subunit alpha 1 | 5850.09 | 1184.12 | − 2.30 | 2.81e−05 | |
IL15 | Interleukin 15 | 240.69 | 50.03 | − 2.26 | 4.34e−02 | |
IL2RB | Interleukin 2 receptor subunit beta | 8781.96 | 733.82 | − 3.58 | 8.80e−08 | |
IL2RG | Interleukin 2 receptor subunit gamma | 6894.04 | 33.36 | − 7.69 | 1.12e−11 | |
IL6R | Interleukin 6 receptor | 19003.48 | 4036.01 | − 2.24 | 3.77e−07 | |
KEAP1 | Kelch like ECH associated protein 1 | 1894.69 | 283.52 | − 2.74 | 6.23e−07 | |
MGST1 | Microsomal glutathione S− transferase 1 | 385.27 | 16.68 | − 4.52 | 8.22e−03 | |
PDGFA | Platelet derived growth factor subunit A | 29.57 | 150.10 | 2.37 | 1.98e−02 | |
PDGFRB | Platelet derived growth factor receptor beta | 314.64 | 0 | − 6.68 | 7.00e−03 | |
PIK3R3 | Phosphoinositide− 3− kinase regulatory subunit 3 | 152.15 | 0 | − 5.62 | 2.17e−02 | |
RALB | RAS like proto− oncogene B | 7354.73 | 1417.61 | − 2.38 | 4.91e−09 | |
RALGDS | Ral guanine nucleotide dissociation stimulator | 959.68 | 16.68 | − 5.85 | 4.33e−04 | |
RASSF1 | Ras association domain family member 1 | 5456.91 | 717.14 | − 2.93 | 1.40e−13 | |
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1 | 1679.24 | 6804.51 | 2.02 | 1.61e−10 | |
TGFA | Transforming growth factor alpha | 951.89 | 50.03 | − 4.25 | 2.30e−04 | |
TXNRD3 | Thioredoxin reductase 3 | 18.50 | 133.42 | 2.78 | 1.63e−03 | |
Proliferation | APC | APC regulator of WNT signaling pathway | 1038.06 | 12174.73 | 3.55 | 1.22e−15 |
BRAF | B− Raf proto− oncogene, serine/threonine kinase | 1366.54 | 9206.1 | 2.75 | 1.26e−17 | |
CCND2 | Cyclin D2 | 4458.14 | 66.71 | − 6.06 | 2.79e−14 | |
CCND3 | Cyclin D3 | 16147.13 | 3485.64 | − 2.21 | 1.37e−06 | |
CCNE2 | Cyclin E2 | 27.48 | 316.88 | 3.53 | 2.98e−03 | |
FGFR2 | Fibroblast growth factor receptor 2 | 85.98 | 950.63 | 3.47 | 4.66e−03 | |
FLT3LG | fms related tyrosine kinase 3 ligand | 92.37 | 0 | − 4.90 | 4.48e−02 | |
FZD1 | Frizzled class receptor 1 | 271.89 | 50.03 | − 2.44 | 2.45e−02 | |
FZD6 | Frizzled class receptor 6 | 64.00 | 517.01 | 3.01 | 1.78e−05 | |
HMOX1 | Heme oxygenase 1 | 3398.05 | 733.82 | − 2.21 | 1.22e−03 | |
HRAS | HRas proto− oncogene, GTPase | 460.16 | 83.39 | − 2.46 | 2.96e−03 | |
IGF1R | Insulin like growth factor 1 receptor | 2771.65 | 11591.01 | 2.06 | 1.07e−03 | |
KEAP1 | Kelch like ECH associated protein 1 | 1894.69 | 283.52 | − 2.74 | 6.23e−07 | |
LRP6 | LDL receptor related protein 6 | 55.66 | 1400.93 | 4.64 | 7.96e−06 | |
MAPK3 | Mitogen− activated protein kinase 3 | 5762.75 | 1334.22 | − 2.11 | 1.12e−04 | |
MGST1 | Microsomal glutathione S− transferase 1 | 385.27 | 16.68 | − 4.52 | 8.22e−03 | |
PDGFA | Platelet derived growth factor subunit A | 29.57 | 150.10 | 2.37 | 1.98e−02 | |
PDGFB | Platelet derived growth factor subunit B | 171.69 | 0 | − 5.81 | 1.63e−02 | |
PDGFRB | Platelet derived growth factor receptor beta | 314.64 | 0 | − 6.68 | 7.00e−03 | |
RB1 | RB transcriptional corepressor 1 | 1225.51 | 10390.22 | 3.08 | 8.52e−20 | |
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1 | 1679.24 | 6804.51 | 2.02 | 1.61e−10 | |
TGFA | Transforming growth factor alpha | 951.89 | 50.03 | − 4.25 | 2.30e−04 | |
TXNRD3 | Thioredoxin reductase 3 | 18.50 | 133.42 | 2.78 | 1.63e−03 | |
WNT10B | Wnt family member 10B | 229.22 | 0 | − 6.22 | 9.03e−03 | |
Sustained angiogenesis | BRAF | B− Raf proto− oncogene, serine/threonine kinase | 1366.54 | 9206.10 | 2.75 | 1.26e−17 |
FGFR2 | Fibroblast growth factor receptor 2 | 85.98 | 950.63 | 3.47 | 4.66e−03 | |
FLT3LG | fms related tyrosine kinase 3 ligand | 92.37 | 0 | − 4.90 | 4.48e−02 | |
HRAS | HRas proto− oncogene, GTPase | 460.16 | 83.39 | − 2.46 | 2.96e−03 | |
IGF1R | Insulin like growth factor 1 receptor | 2771.65 | 11591.01 | 2.06 | 1.07e−03 | |
JAG1 | Jagged canonical Notch ligand 1 | 99.62 | 517.01 | 2.37 | 2.68e−04 | |
MAPK3 | Mitogen− activated protein kinase 3 | 5762.75 | 1334.22 | − 2.11 | 1.12e−04 | |
NOTCH2 | Notch receptor 2 | 8983.16 | 39609.57 | 2.14 | 6.81e−07 | |
PDGFA | Platelet derived growth factor subunit A | 29.57 | 150.10 | 2.37 | 1.98e−02 | |
PDGFB | Platelet derived growth factor subunit B | 171.69 | 0 | − 5.81 | 1.63e−02 | |
PDGFRB | Platelet derived growth factor receptor beta | 314.64 | 0 | − 6.68 | 7.00e−03 | |
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1 | 1679.24 | 6804.51 | 2.02 | 1.61e−10 | |
TGFA | Transforming growth factor alpha | 951.89 | 50.03 | − 4.25 | 2.30e−04 | |
TGFB1 | Transforming growth factor beta 1 | 28839.34 | 6287.5 | − 2.20 | 1.64e−04 | |
Genomic instability | BAD | BCL2 associated agonist of cell death | 826.17 | 116.74 | − 2.82 | 5.74e−05 |
BBC3 | BCL2 binding component 3 | 1275.40 | 66.71 | − 4.26 | 5.98e−06 | |
Insensitivity to anti−growth signals | SMAD2 | SMAD family member 2 | 2524.65 | 10957.26 | 2.12 | 3.49e−32 |
TGFB1 | Transforming growth factor beta 1 | 28839.34 | 6287.5 | − 2.20 | 1.64e−04 |