Table 1 Overview of different differential diagnoses for decreased ALP activity. Modified from (13)
| Causes of low ALP activity |
|---|
| Hypophosphatasia (HPP) |
| Osteogenesis imperfecta |
| Cleidocranial dysplasia |
| Mseleni joint disease |
| Vitamin D intoxication |
| Multiple myeloma |
| Wilson's disease |
| Vitamin C deficiency |
| hypothyroidism |
| Zn++ or Mg++ deficiency |
| Cushing's syndrome |
| Milk-alkali syndrome |
| Celiac disease |
| Starvation |
| Bisphosphonate therapy |