Multivariate data analysis identifies natural clusters of Tuberous Sclerosis Complex Associated Neuropsychiatric Disorders (TAND)

Table 1 Seven natural TAND clusters identified in this study

Natural TAND cluster	No. of items	TAND checklist items	Internal consistency (alpha)
Scholastic	4	Reading Writing Spelling Mathematics	0.97^a
Neuropsychological	7	Memory Disorientation Attention difficulties (behaviour) Neuropsychological attention deficits Visuo-spatial Dual-tasking Executive skills	0.87^a
Autism Spectrum Disorder-Like	6	Inflexible Unusual language Repetitive behaviour Poor eye contact Peer difficulties Delayed language	0.79^a
Dysregulated behaviour	3	Aggressive outbursts Temper tantrums Self-injury	0.73^a
Overactive/Impulsive	3	Overactive Impulsive Restless	0.70^a
Mood/Anxiety	4	Mood swings Anxiety Depressed mood Extreme shyness	0.69
Eat/Sleep	2	Eating difficulties Sleep difficulties	0.48

The table shows the clusters with items contained and internal consistency of each cluster
^aCronbach alpha ≥ 0.7 indicates good internal consistency

ISSN: 1750-1172