Table 1 Descriptive data of women with chronic HypoPT and pseudo-HypoPT at the pre-pregnancy period (previous six months), regarding pharmacological treatment, biochemical exams, clinical manifestations, and other data
Hypo-PT (n = 25) | Pseudo-HypoPT (n = 3) | |||||
|---|---|---|---|---|---|---|
Medications | Number | Mean ± SD | Range | Number | Mean ± SD | Range |
Calcium carbonate, mg/day | 24 | 1.416.7 ± 876.5 | 500–4000 | 3 | 500 | – |
Calcium citrate, mg/day | 1 | 500 | – | 0 | 0 | – |
Calcitriol, µg/day | 25 | 0.79 ± 0.51 | 0.25–3.0 | 3 | 0.67 ± 0.14 | 0.50–0.75 |
Alfacalcidol, µg/day | 1 | 0.25 | 0.25 | 0 | 0 | – |
Cholecalciferol, IU/day | 9 | 977.5 ± 413.4 | 400–1600 | 1 | 1,600 | – |
Biochemistrya | ||||||
|---|---|---|---|---|---|---|
Albumin-corrected calcium, mg/dl [8.5–10.1] | 15 | 8.2 ± 0.7 | 6.8–9.1 | 2 | 9.3 ± 0.7 | 8.8–9.8 |
Total calcium serum, mg/dl [8.5–10.1] | 25 | 8.3 ± 0.8 | 6.7–9.6 | 3 | 9.1 ± 0.3 | 8.8–9.3 |
Phosphate serum, mg/dl [2.5–4.9] | 19 | 4.3 ± 1.3 | 0.9–6.4 | 3 | 4.6 ± 0.7 | 3.8–5.1 |
Urinary calcium, mg/24 h [100–300] | 10 | 201.3 ± 87.2 | 68–353.8 | 3 | 122 ± 96.3 | 36.0–226 |
Creatinine, mg/dl [0.5–1.3] | 16 | 0.7 ± 0.1 | 0.5–0.9 | 3 | 0.7 ± 0.1 | 0.6–0.8 |
Creatinine Clearance, ml/min [> 60] | 12 | 98.6 ± 16.0 | 76.6–120 | 3 | 76.3 ± 11.8 | 69.0–90 |
PTH, pg/ml [10–65] | 24 | 8.5 ± 4.1 | 1–18 | 3 | 40.3 ± 23.7 | 14.0–59.9 |
25 (OH) vitamin D, ng/ml [30–100] | 23 | 28.9 ± 11.1 | 13.4–50.2 | 3 | 16.5 ± 8.8 | 8.5–26 |
Magnesium, mg/dl [1.5–2.6] | 12 | 1.8 ± 0.4 | 0.8–2.2 | 3 | 1.9 ± 0.3 | 1.7–2.2 |
Miscellanea | ||||||
|---|---|---|---|---|---|---|
Average duration of chronic HypoPT before the first pregnancy | 25 | 4.6 ± 3.6 | 1–15 | – | – | – |
Average age at first pregnancy | 25 | 32.3 ± 5.3 | 21–45 | 3 | 33.6 ± 6 | 28–40 |
Mean dietary calcium intake, mg/daily | 7 | 800 ± 230.9 | 500–1100 | – | – | – |
Body weight (Kg) | 25 | 63.9 ± 14.0 | 43–100 | 3 | 62 ± 7.2 | 56–70 |
Hypo-PT or Pseudo-HypoPT-related Clinical Manifestationsb | Number (Denominator) | Number (Numerator) | Frequency | Number (Denominator) | Number (Numerator) | Frequency |
|---|---|---|---|---|---|---|
Paresthesia | 25 | 13 | 52% | 3 | 1 | 33.3% |
Cramps/tetany | 25 | 3 | 12% | 3 | 0 | 0 |
Kidney stones | 25 | 1 | 4% | 3 | 1 | 33.3% |
Extraskeletal calcifications | 25 | 0 | 0 | 3 | 2 | 66.7% |