Executive functions and quality of life in children with neurofibromatosis type 1

Table 4 Predictors of quality of life in children with NF1 (n = 40). Results of regression analysis

				QoL
	Child self-report			Parent proxy report
	Ph WB	Soc sup	Sch env	Ph WB	Moods em	Par rel	Soc sup	Sch env	Soc Acc
Model 1 Executive functions
ROCF, planning index		− 1.7 (0.7)**	− 1.2 (0.6)*						− 1.3 (0.4)***
Stroop, errors
WMI		− 0.4 (0.2)*					− 0.4 (0.2)*
T2B speed			− 0.2 (0.1)*			− 0.1 (0.1)*		− 0.1 (0.1)*	− 0.1 (0.1)*
T2B accuracy
Auditory attention
BRIEF parents, BRI					− 0.5 (0.2)*				− 0.4 (0.2)*
BRIEF parents, MI							− 0.6 (0.3)^†	− 0.5 (0.2)**
BRIEF teacher, BRI
BRIEF teacher, MI		− 0.4 (0.2)^†	− 0.4 (0.2)^†	− 0.3 (0.1)*					− 0.5 (0.2)**
Model 2 Sociodemographic and disease-related factors
Age						− 0.2 (0.1)*
Sex (boys)	2.7 (1.5)^†		9.5 (4.2)*		10.6 (3.7)**				7.2 (3.6)*
PEL
Sporadic NF1
Severity					− 4.7 (2.8)^†	− 6.0 (2.8)*	− 8.3 (3.1)**
Visibility	− 4.0 (1.7)*	− 15.9 (5.7)**	− 9.6 (4.9)*
Indirect LD indicators
School support	− 0.27 (0.1)^†
Extracurricular support									− 0.1 (0.1)^†

QoL = quality of life; PhWB = physical wellbeing; Soc sup = social support and peers; Sch env = school environment; Moods em = moods and emotions; Par rel = parental relations and home life; Soc acc = social acceptance; ROCF = Rey–Osterrieth complex figure; WMI = working memory index; T2B = two barrages test; BRIEF = behavior rating inventory of executive function; GEC = global executive composite; BRI = behavioral regulation index; MI = metacognition index; PEL = parental education level; LD = learning disabilities. Severity is based on Riccardi scale. Visibility is based on Ablon scale
***p < 0.001; **p < 0.01; *p < 0.05; ^†p < 0.10

ISSN: 1750-1172