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Table 2 Biochemical changes (mean ± SD) during ketogenic diet

From: Ketogenic diet as elective treatment in patients with drug-unresponsive hyperinsulinemic hypoglycemia caused by glucokinase mutations

 

Patient 1

Patient 2

Patient 3

Mean

KD ketonemia (mmol/L)

3.1 ± 0.9

3.4 ± 0.9

4.6 ± 0.9

3.7 ± 0.8

Glycemia (mmol/L)

2.8 ± 0.4

2.2 ± 0.8

2.2 ± 0

2.4 ± 0.3

KD glycemia (mmol/L)

1.9 ± 0.2***

1.6 ± 0.3*

2.0 ± 0.4

1.8 ± 0.2

Insulin (μU/mL)

12.2 ± 5.1

18.2 ± 8.9

4.2 ± 0.7

11.5 ± 7.0

KD insulin (μU/mL)

10.1 ± 5.3

6.1 ± 4.9**

5.1 ± 2.1

7.1 ± 2.6

CGMS time in hypoglycemia (%)

32

68

50

50 ± 18

KD CGMS time in hypoglycemia (%)

37

100

100

79 ± 36.3

  1. HbA1c n.v. 20–42 mmol/L; NA not available; *p < 0.05; **p < 0.01; ***p < 0.001