Fig. 3

Secondary efficacy endpoints results. Baseline-adjusted mean change in time to walk 10 m in the modified full analysis set (no imputation) for the high-dose, low-dose and placebo groups over the course of the study is shown in panel A (error bars are standard errors of the mean). Treatment effect vs placebo as measured by baseline-adjusted change with multiple imputation for all secondary endpoints are shown in panel B (error bars are 97.5% confidence intervals). The vertical axis is reversed to show that negative numbers indicate improvement. 10MWT: 10 m walk test (time to walk 10 m), CMTNSv2-S and E: Charcot–Marie–Tooth Neuropathy Scale version 2 Sensory and Examination scores, 9HPT: nine-hole peg test