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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot–Marie–Tooth type 1A

Fig. 2

Primary efficacy endpoint results. Mean change in Overall Neuropathy Limitations Scale (ONLS) total score in the modified full analysis set (mFAS, no imputation) high-dose PXT3003 (dark grey), low-dose PXT3003 (medium grey) and placebo (light grey) groups over the course of the study (panel A, error bars are standard error of the mean). The treatment effect vs placebo as measured by baseline-adjusted change with multiple imputation in ONLS score is shown in panel B for the primary analysis and the first sensitivity analysis (FAS: full analysis set). Panel C shows the second sensitivity analysis (LG: longitudinal model). The error bars in B and C are 97.5% confidence intervals. Axes are reversed to emphasize that lower ONLS scores indicate improvement

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