Table 2 The gender reassignment in 46, XY DSD patients with different ages and etiologies
Age | Group | n | Age of first vist (year) M (QL–QU) | Age of gender re-assignment (year) M (QL–QU) | Follow-up period (year) M (QL–QU) | Age at study (year) M (QL–QU) | Male gender at birth n (%) | Male gender after diagnosis n (%) |
|---|---|---|---|---|---|---|---|---|
2–7 years (n = 66) | 5α-RD2 | 33 | 1.5 (0.8–2.7) | 2.0 (1.1–3.1) | 2.0 (1.4–2.5) | 4.0 (3.5–5.6) | 25 (75.7%) | 33 (100%) |
CAIS | 8 | 2.6 (1.9–4.6) | 2.9 (2.0–4.6) | 0.9 (0.5–1.2) | 4.1 (3.0–5.3) | 0 | 0 | |
PAIS | 12 | 1.2 (0.7–2.1) | 1.6 (0.8–2.4) | 2.0 (1.0–3.2) | 4.0 (2.5–5.1) | 11 (91.6%) | 12 (100%) | |
NR5A1 | 7 | 1.0 (0.6–1.3) | 1.3 (1.0–1.5) | 2.0 (1.0–2.0) | 3.0 (2.5–3.2) | 5 (71.4%) | 7 (100%) | |
CYP17A1 | 6 | 1.9 (1.2–3.2) | 2.1 (1.3–4.1) | 2.6 (1.3–4.0) | 5.9 (4.0–6.7) | 0 | 0 | |
Control Males | 52 | – | – | – | 4.7 (4.0–5.1)a | – | – | |
Control Females | 14 | – | – | – | 5.0 (3.3–6.2)b | – | – | |
8–18 years (n = 46) | 5α-RD2 | 22 | 5.8 (1.0–9.7) | 6.7 (1.3–11.2) | 4.3 (1.1–7.8) | 10.6 (8.9–13.0) | 14 (63.6%) | 22 (100%) |
CAIS | 8 | 7.2 (1.5–8.9) | 7.9 (6.9–8.9) | 1.0 (0.7–3.1) | 9.5 (8.6–10.0) | 0 | 0 | |
PAIS | 8 | 4.4 (2.2–6.3) | 4.6 (3.0–11.1) | 4.5 (1.7–6.3) | 10.5 (8.0–13.7) | 3 (37.5%) | 7 (87.5%) | |
NR5A1 | 5 | 6.1 (1.1–12.4) | 6.3 (1.9–12.9) | 1.9 (1.4–7.3) | 10.0 (8.1–14.3) | 3 (60.0%) | 5 (100%) | |
CYP17A1 | 3 | 12.0 (–) | 12.7 (–) | 1.9 (–) | 13.2 (–) | 1 (33.3%) | 1 (33.3%) | |
Control Males | 35 | – | – | – | 10.4(9.5–12.0)c | – | – | |
Control Females | 11 | – | – | – | 10.5(9.7–12.7)d | – | – |