Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) in a phase 2 clinical study

Table 5 Distribution-based methods to estimate clinically important difference for ISM-SAF biweekly domain and total scores

ISM-SAF biweekly domain	n	Reliability^a	1/2 SD	SEm
Total Symptom Score	37	0.86	9.53	7.22
Gastrointestinal Symptom Score	37	0.83	3.48	2.86
Skin Symptom Score	38	0.82	3.76	3.19

ISM-SAF = Indolent Systemic Mastocytosis Symptom Assessment Form; SD = standard deviation, SEm = standard error of measurement (SD at Baseline multiplied by the square root of [1-reliability])
^aReliability estimate from Baseline Cronbach’s alpha internal consistency reliability estimates

ISSN: 1750-1172