|
Concurrent scores
|
Pearson correlationb
|
|---|
|
Total symptom score
|
Gastrointestinal symptom score
|
Skin symptom score
|
|---|
|
SF-12v2®
|
|
Physical functioning
|
− 0.390
|
− 0.329
|
− 0.212
|
|
Role-physical
|
− 0.566
|
− 0.357
|
− 0.348
|
|
Bodily pain
|
− 0.459
|
− 0.421
|
− 0.056
|
|
General health
|
− 0.558
|
− 0.363
|
− 0.306
|
|
Vitality
|
− 0.518
|
− 0.354
|
− 0.170
|
|
Social functioning
|
− 0.358
|
− 0.365
|
− 0.275
|
|
Role-emotional
|
− 0.255
|
− 0.329
|
− 0.166
|
|
Mental health
|
− 0.215
|
− 0.216
|
− 0.178
|
|
MCS
|
− 0.226
|
− 0.275
|
− 0.179
|
|
PCS
|
− 0.536
|
− 0.368
|
− 0.218
|
|
MC-QoL
|
|
Symptoms
|
0.695
|
0.541
|
0.382
|
|
Social life/functioning
|
0.624
|
0.498
|
0.498
|
|
Emotions
|
0.456
|
0.399
|
0.329
|
|
Skin
|
0.530
|
0.265
|
0.881
|
|
Total score
|
0.695
|
0.538
|
0.550
|
|
EQ-5D-5L
|
|
EQ-5D-5L VAS
|
− 0.612
|
− 0.432
|
− 0.328
|
|
PGIS
|
|
PGIS
|
0.656[a]
|
0.401[a]
|
0.618[a]
|
- ISM-SAF biweekly item scores range from 0 to 10 with higher scores associated with worse signs and symptoms, with the exception of Item 11, which asks about frequency of events. ISM-SAF biweekly domain scores range from 0 to 30 and total score ranges from 0 to 110 with higher scores associated with more severe signs and symptoms. The SF-12v2® scores are norm-based normalized to United States general population with mean 50 and standard deviation of 10, with higher score indicating better functioning or well-being. The MC-QoL scores range from 0 to 100 where higher scores represent more health-related quality of life impairment. The EQ-5D-5L VAS ranges from 0 to 100 where higher scores represent better health states
- C#D# cycle number, day number, EQ-5D-5L five-level EQ-5D, ISM-SAF Indolent Systemic Mastocytosis Symptom Assessment Form, MC-QoL Mastocytosis Quality of Life Questionnaire, MCS Mental Component Summary, PCS Physical Component Summary, PGIS Patient Global Impression of Severity, VAS visual analogue scale
- aN value is based on number of subjects with both ISM-SAF domain scores and concurrent scores available at Baseline
- bCorrelations and p-values were calculated as Pearson's correlations and Fisher's z-transformation except [a]ordinal variables where correlations and p-values were calculated using polyserial correlations and likelihood ratio tests
