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Table 3 Pearson correlations of ISM-SAF total and domain scores with other measures administered at C4D1 (N = 34a)

From: Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) in a phase 2 clinical study

Concurrent scores Pearson correlationb
Total symptom score Gastrointestinal symptom score Skin symptom score
SF-12v2®
Physical functioning − 0.390 − 0.329 − 0.212
Role-physical − 0.566 − 0.357 − 0.348
Bodily pain − 0.459 − 0.421 − 0.056
General health − 0.558 − 0.363 − 0.306
Vitality − 0.518 − 0.354 − 0.170
Social functioning − 0.358 − 0.365 − 0.275
Role-emotional − 0.255 − 0.329 − 0.166
Mental health − 0.215 − 0.216 − 0.178
MCS − 0.226 − 0.275 − 0.179
PCS − 0.536 − 0.368 − 0.218
MC-QoL
Symptoms 0.695 0.541 0.382
Social life/functioning 0.624 0.498 0.498
Emotions 0.456 0.399 0.329
Skin 0.530 0.265 0.881
Total score 0.695 0.538 0.550
EQ-5D-5L
EQ-5D-5L VAS − 0.612 − 0.432 − 0.328
PGIS
PGIS 0.656[a] 0.401[a] 0.618[a]
  1. ISM-SAF biweekly item scores range from 0 to 10 with higher scores associated with worse signs and symptoms, with the exception of Item 11, which asks about frequency of events. ISM-SAF biweekly domain scores range from 0 to 30 and total score ranges from 0 to 110 with higher scores associated with more severe signs and symptoms. The SF-12v2® scores are norm-based normalized to United States general population with mean 50 and standard deviation of 10, with higher score indicating better functioning or well-being. The MC-QoL scores range from 0 to 100 where higher scores represent more health-related quality of life impairment. The EQ-5D-5L VAS ranges from 0 to 100 where higher scores represent better health states
  2. C#D# cycle number, day number, EQ-5D-5L five-level EQ-5D, ISM-SAF Indolent Systemic Mastocytosis Symptom Assessment Form, MC-QoL Mastocytosis Quality of Life Questionnaire, MCS Mental Component Summary, PCS Physical Component Summary, PGIS Patient Global Impression of Severity, VAS visual analogue scale
  3. aN value is based on number of subjects with both ISM-SAF domain scores and concurrent scores available at Baseline
  4. bCorrelations and p-values were calculated as Pearson's correlations and Fisher's z-transformation except [a]ordinal variables where correlations and p-values were calculated using polyserial correlations and likelihood ratio tests