In-depth phenotyping for clinical stratification of Gaucher disease

Table 7 Impact of splenectomy on skeletal manifestations since presentation of Gaucher disease

		Hazard ratio	P-value	[95% CI]
1st fragility fracture	Splenectomy	2.83	0.01	1.33	5.99
N = 247	Gender effect	1.04	0.91	0.52	2.07
Multiple fragility fractures*	Splenectomy	5.78	<0.0001	2.32	14.42
N = 247	Gender effect	0.59	0.17	0.28	1.24
1st osteonecrosis	Splenectomy	2.95	<0.0001	1.74	5.00
N = 246	Gender	0.80	0.37	0.48	1.31
Osteonecrosis events*	Splenectomy	3.32	<0.0001	1.98	5.56
N = 246	Gender effect	0.95	0.83	0.59	1.53
Presence of Erlenmeyer flask deformity	Splenectomy	0.98	0.95	0.59	1.64
N = 248	Gender effect	0.80	0.34	0.50	1.27
Presence of lytic lesions	Splenectomy	2.70	0.12	0.76	9.52
N = 248	Gender effect	0.26	0.08	0.06	1.16
Orthopaedic surgery	Splenectomy	1.99	0.01	1.15	3.44
N = 244	Gender effect	0.84	0.52	0.50	1.41

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