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Table 1 Clinical and biochemical characteristics of the study population

From: Modifiable factors affecting renal preservation in type I glycogen storage disease after liver transplantation: a single-center propensity-match cohort study

 

GSD group (n = 9)

BA group (n = 20)

P value

Age at LT (years)

9.0 (4.2–15.7)

4.8 (0.7–17)

0.144

Female sex, n (%)

6 (67%)

10 (50.0%)

0.412

Body weight (kg)

20.6 (12.0–57.3)

16.8 (8.2–63.8)

0.437

Body height (cm)

113 (92–151)

105 (76–170)

0.571

PELD score

0 (− 4 to 6.0)

− 0.5 (− 10 to 16)

1.000

Preoperative laboratory variables

   

 Albumin (g/dL)

4.2 (3.1–5.3)

3.8 (1.9–4.5)

0.013

 Total bilirubin (mg/dL)

0.5 (0.1–1.0)

1.9 (0.3–17.1)

0.001

 Creatinine (mg/dL)

0.5 (0.3–0.9)

0.4 (0.1–0.6)

0.187

 eGFR (ml/min/1.73 m2)

104 (58–135)

125 (76–234)

0.238

Perioperative variables

   

 GRWR

1.63 (1.27–2.69)

1.9 (1.0–3.8)

0.976

 Blood loss (ml)

120 (20–1480)

130 (35–460)

0.698

 Adenoma

4 (44%)

0 (0%)

0.002

 Post-LT AKI, n (%)

4 (23.5%)

13 (76.5%)

0.422

Immunosuppressive regimen

   

 Cyclosporin initially, n (%)

9 (100%)

20 (100%)

1.000

 Tacrolimus conversion, n (%)

2 (22%)

5 (25%)

0.874

 mTOR conversion, n (%)

3 (33%)

0 (0%)

0.044

 Rejection, n (%)

2 (22%)

4 (20%)

0.893

 De novo HTN, n (%)

2 (22%)

0 (0%)

0.032

Postoperative variables

   

 Total bilirubin (mg/dL)

0.8 (0.7–1.1)

1.1 (0.4–1.8)

0.177

 Creatinine (mg/dL)

0.7 (0.5–3.1)

0.7 (0.5–1.0)

0.813

 eGFR (ml/min/1.73 m2)

111 (18–175)

123 (73–174)

0.268

 eGFR < 60 (ml/min/1.73m2), n (%)

2 (22%)

0 (0%)

0.032

Albuminuria

   

 Microalbuminuria (ACR, mg/g)

16.0 (5.6–1047)

7.2 (2.5–68.6)

0.099

 Macroalbuminuria (ACR ≥ 300 mg/g)

2 (22%)

0 (0%)

0.089

 Follow up (years)

15.4 (4.1–22.4)

15.4 (4.7–24.3)

0.637

  1. Values are expressed as median (range) or number (percentage)
  2. ACR—urine microalbuminuria to creatinine ratio; AKI—acute kidney injury; BA—biliary atresia; CKD—chronic kidney disease, defined by KDIGO 2012 guideline; eGFR—estimated glomerular filtration rate; GRWR—graft to recipient weight ratio; GSD—glycogen storage disease; HTN—hypertension; LT—liver transplantation; mTOR—mammalian target of rapamycin; PELD score—pediatric end-stage liver disease score