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Table.2 Results of the cluster analysis

From: Variables affecting pricing of orphan drugs: the Italian case

Cluster Prevalence Number of medicines ASMR RCT Annual treatment cost (€) Regression coefficient, 95% confidence interval
1 Low 13 Mean: 3.77 Yes 294,514  
2 Low 11 Mean: 3.91 No 107,297 − 1.06 (− 1.82, − 0.31)
3 High 6 Mean: 3.83 No 187,370 − 0.21 (− 1.12, 0.69)
4 High 22 Mean: 4.09 Yes 63,855 − 1.26 (− 1.9, − 0.62)
  1. Cluster analysis based on Gower distance and Partition Around Medoids algorithm. Low/high prevalence = below/above median; no/yes RCT = no RCT/all RCT. 52 medicines were included (the ones for which we have complete information on RCT and ASMR). ASMR Amélioration du Service Médical Rendu, RCT Randomized Clinical Trial