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Table.2 Results of the cluster analysis

From: Variables affecting pricing of orphan drugs: the Italian case

Cluster

Prevalence

Number of medicines

ASMR

RCT

Annual treatment cost (€)

Regression coefficient, 95% confidence interval

1

Low

13

Mean: 3.77

Yes

294,514

 

2

Low

11

Mean: 3.91

No

107,297

− 1.06 (− 1.82, − 0.31)

3

High

6

Mean: 3.83

No

187,370

− 0.21 (− 1.12, 0.69)

4

High

22

Mean: 4.09

Yes

63,855

− 1.26 (− 1.9, − 0.62)

  1. Cluster analysis based on Gower distance and Partition Around Medoids algorithm. Low/high prevalence = below/above median; no/yes RCT = no RCT/all RCT. 52 medicines were included (the ones for which we have complete information on RCT and ASMR). ASMR Amélioration du Service Médical Rendu, RCT Randomized Clinical Trial