Fig. 3

Clinical characteristics at diagnosis of patients with non-HFE-related HH. The presence or absence of clinical characteristics was determined in all patients with genetic diagnosis of HJV HH, SLC40A1 HH, SUGP2 or DENND3 HH and HH without pathogenic or likely pathogenic variants. A Cirrhosis, B Skin pigmentation, C Arthropathy, D Cardiac involvement, E Diabetes and F Hypogonadism at diagnosis are shown for subjects in the four groups. Variables were compared using chi-square test and Fisher’s exact test. Differences in clinical characteristics with Cirrhosis, Cardiac involvement, Hypogonadism were statistically significant in the four groups. However, due to the limited sample size, the pairwise comparison showed no significant difference