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Table 7 Results of DIF analyses over time

From: Norm-based comparison of the quality-of-life impact of ravulizumab and eculizumab in paroxysmal nocturnal hemoglobinuria

Item Label Domain DIF over time within PNH patients
Test of uniform DIF Test of non-uniform DIF
p value (on group effect) "Favored" group Odds ratio on group effectφ p value (on interaction term)
eortc29 29. How would you rate your overall health during the past week? Global NS NS NS NS
eortc30 30. How would you rate your overall quality of life during the past week? Global NS NS NS NS
eortc01 1. Do you have any trouble doing strenuous activities, like carrying a heavy shopping bag or a suitcase? Physical p = .001 As time increases, the likelihood of endorsing decreases 0.94 NS
eortc02 2. Do you have any trouble taking a long walk? Physical p = .008 As time increases, the likelihood of endorsing decreases 0.95 NS
eortc03 3. Do you have any trouble taking a short walk outside of the house? Physical NS NS NS NS
eortc04 4. Do you need to stay in bed or a chair during the day? Physical NS NS NS NS
eortc05 5. Do you need help with eating, dressing, washing yourself or using the toilet? Physical NS NS NS NS
eortc06 6. Were you limited in doing either your work or other daily activities? Role p < .001 As time increases, the likelihood of endorsing increases 1.08 NS
eortc07 7. Were you limited in pursuing your hobbies or other leisure time activities? Role p < .001 As time increases, the likelihood of endorsing decreases 0.90 NS
eortc21 21. Did you feel tense? Emotional NS NS NS NS
eortc22 22. Did you worry? Emotional NS NS NS NS
eortc23 23. Did you feel irritable? Emotional p = .009 As time increases, the likelihood of endorsing increases 1.04 p = .031
eortc24 24. Did you feel depressed? Emotional NS NS NS NS
eortc20 20. Have you had difficulty in concentrating on things, like reading a newspaper or watching television? Cognitive NS NS NS NS
eortc25 25. Have you had difficulty remembering things? Cognitive NS NS NS NS
eortc26 26. Has your physical condition or medical treatment interfered with your family life? Social NS NS NS NS
eortc27 27. Has your physical condition or medical treatment interfered with your social activities? Social NS NS NS NS
eortc10 10. Did you need to rest? Fatigue NS NS NS NS
eortc12 12. Have you felt weak? Fatigue p < .001 As time increases, the likelihood of endorsing decreases 0.93 NS
eortc18 18. Were you tired? Fatigue NS NS NS p = .003
eortc14 14. Have you felt nauseated? Nauseau NS NS NS NS
eortc15 15. Have you vomited? Nauseau NS NS NS NS
eortc09 9. Have you had pain? Pain NS NS NS p = .002
eortc19 19. Did pain interfere with your daily activities? Pain p = .047 As time increases, the likelihood of endorsing decreases 0.95 NS
  1. *"Favored" = Finds it easier to endorse poor health except for eortc29 and eortc30
  2. φOdds ratio converted to by-month estimate for ease of interpretation (i.e., daily estimate^30)