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Table 7 Results of DIF analyses over time

From: Norm-based comparison of the quality-of-life impact of ravulizumab and eculizumab in paroxysmal nocturnal hemoglobinuria

Item

Label

Domain

DIF over time within PNH patients

Test of uniform DIF

Test of non-uniform DIF

p value (on group effect)

"Favored" group

Odds ratio on group effectφ

p value (on interaction term)

eortc29

29. How would you rate your overall health during the past week?

Global

NS

NS

NS

NS

eortc30

30. How would you rate your overall quality of life during the past week?

Global

NS

NS

NS

NS

eortc01

1. Do you have any trouble doing strenuous activities, like carrying a heavy shopping bag or a suitcase?

Physical

p = .001

As time increases, the likelihood of endorsing decreases

0.94

NS

eortc02

2. Do you have any trouble taking a long walk?

Physical

p = .008

As time increases, the likelihood of endorsing decreases

0.95

NS

eortc03

3. Do you have any trouble taking a short walk outside of the house?

Physical

NS

NS

NS

NS

eortc04

4. Do you need to stay in bed or a chair during the day?

Physical

NS

NS

NS

NS

eortc05

5. Do you need help with eating, dressing, washing yourself or using the toilet?

Physical

NS

NS

NS

NS

eortc06

6. Were you limited in doing either your work or other daily activities?

Role

p < .001

As time increases, the likelihood of endorsing increases

1.08

NS

eortc07

7. Were you limited in pursuing your hobbies or other leisure time activities?

Role

p < .001

As time increases, the likelihood of endorsing decreases

0.90

NS

eortc21

21. Did you feel tense?

Emotional

NS

NS

NS

NS

eortc22

22. Did you worry?

Emotional

NS

NS

NS

NS

eortc23

23. Did you feel irritable?

Emotional

p = .009

As time increases, the likelihood of endorsing increases

1.04

p = .031

eortc24

24. Did you feel depressed?

Emotional

NS

NS

NS

NS

eortc20

20. Have you had difficulty in concentrating on things, like reading a newspaper or watching television?

Cognitive

NS

NS

NS

NS

eortc25

25. Have you had difficulty remembering things?

Cognitive

NS

NS

NS

NS

eortc26

26. Has your physical condition or medical treatment interfered with your family life?

Social

NS

NS

NS

NS

eortc27

27. Has your physical condition or medical treatment interfered with your social activities?

Social

NS

NS

NS

NS

eortc10

10. Did you need to rest?

Fatigue

NS

NS

NS

NS

eortc12

12. Have you felt weak?

Fatigue

p < .001

As time increases, the likelihood of endorsing decreases

0.93

NS

eortc18

18. Were you tired?

Fatigue

NS

NS

NS

p = .003

eortc14

14. Have you felt nauseated?

Nauseau

NS

NS

NS

NS

eortc15

15. Have you vomited?

Nauseau

NS

NS

NS

NS

eortc09

9. Have you had pain?

Pain

NS

NS

NS

p = .002

eortc19

19. Did pain interfere with your daily activities?

Pain

p = .047

As time increases, the likelihood of endorsing decreases

0.95

NS

  1. *"Favored" = Finds it easier to endorse poor health except for eortc29 and eortc30
  2. φOdds ratio converted to by-month estimate for ease of interpretation (i.e., daily estimate^30)