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Table 6 Results of DIF analyses of PNH versus general population

From: Norm-based comparison of the quality-of-life impact of ravulizumab and eculizumab in paroxysmal nocturnal hemoglobinuria

Item Label Domain DIF by Group (PNH vs. general population)
Test of uniform DIF Test of non-uniform DIF
Likelihood ratio test p value "Favored" group Odds ratio on group effect Likelihood ratio test p value "Favored" group at the mean total domain score Odds ratio on group effect at the mean total domain score
eortc29 29. How would you rate your overall health during the past week? Global NS NS NS NS NS NS
eortc30 30. How would you rate your overall quality of life during the past week? Global NS NS NS NS NS NS
eortc01 1. Do you have any trouble doing strenuous activities, like carrying a heavy shopping bag or a suitcase? Physical p < .001 General pop 0.5326 p = .0214 General pop 0.5599
eortc02 2. Do you have any trouble taking a long walk? Physical p < .001 Ecu/Ravu 1.9937 NS NS NS
eortc03 3. Do you have any trouble taking a short walk outside of the house? Physical NS NS NS NS NS NS
eortc04 4. Do you need to stay in bed or a chair during the day? Physical NS NS NS p = .0089 Ecu/Ravu 1.0833
eortc05 5. Do you need help with eating, dressing, washing yourself or using the toilet? Physical NS NS NS NS NS NS
eortc06 6. Were you limited in doing either your work or other daily activities? Role NS NS NS NS NS NS
eortc07 7. Were you limited in pursuing your hobbies or other leisure time activities? Role NS NS NS NS NS NS
eortc21 21. Did you feel tense? Emotional p < .001 General pop 0.2567 NS NS NS
eortc22 22. Did you worry? Emotional NS NS NS p < .001 Ecu/Ravu 1.3910
eortc23 23. Did you feel irritable? Emotional p < .001 Ecu/Ravu 2.8577 NS NS NS
eortc24 24. Did you feel depressed? Emotional p < .001 General pop 0.5886 p < .001 General pop 0.7189
eortc20 20. Have you had difficulty in concentrating on things, like reading a newspaper or watching television? Cognitive p < .001 General pop 0.2165 p < .001 General pop 0.1177
eortc25 25. Have you had difficulty remembering things? Cognitive p < .001 Ecu/Ravu 1.9155 p < .001 Ecu/Ravu 1.6161
eortc26 26. Has your physical condition or medical treatment interfered with your family life? Social p < .001 General pop 0.3198 p = .0003 General pop 0.5326
eortc27 27. Has your physical condition or medical treatment interfered with your social activities? Social p < .001 General pop 0.3135 p < .001 General pop 0.1755
eortc10 10. Did you need to rest? Fatigue p < .001 General pop 0.3642 NS NS NS
eortc12 12. Have you felt weak? Fatigue NS NS NS NS NS NS
eortc18 18. Were you tired? Fatigue p < .001 Ecu/Ravu 2.4351 p < .001 Ecu/Ravu 2.4843
eortc14 14. Have you felt nauseated? Nauseau p = .0253 Ecu/Ravu 1.8589 p < .001 General pop 0.4916
eortc15 15. Have you vomited? Nauseau p = .0006 General pop 0.1791 NS NS NS
eortc09 9. Have you had pain? Pain p < .001 General pop 0.3012 NS NS NS
eortc19 19. Did pain interfere with your daily activities? Pain NS NS NS p < .001 Ecu/Ravu 1.4191
  1. *"Favored" = Finds it easier to endorse poor health except for eortc29 and eortc30