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Table 1 Demographic, clinical and anthropometric variables in SMA1 and SMA2 children

From: Growth patterns in children with spinal muscular atrophy

  SMA1 SMA2
Male Female Total Male Female Total
N = 58 (43.6%) N = 75 (56.4%) N = 133 N = 42 (51.2%) N = 40 (48.8%) N = 82
Demographic variables       
Age (years) 0.7 (0.4; 2.1) 0.6 (0.4; 1.4) 0.6 (0.4; 1.6) 4.3 (2.2; 7.0) 3.9 (1.9; 6.7) 4.1 (2.1; 6.7)
Age classes       
 0–1 year 35 (60.3%) 51 (68.0%) 86 (64.7%) 1 (2.4%) 0 (0.0%) 1 (1.2%)
 1–3 years 14 (24.1%) 10 (13.3%) 24 (18.0%) 12 (28.6%) 15 (37.5%) 27 (32.9%)
 3–6 years 4 (6.9%) 8 (10.7%) 12 (9.0%) 15 (35.7%) 13 (32.5%) 28 (34.1%)
 6–10 years 3 (5.2%) 4 (5.3%) 7 (5.3%) 9 (21.4%) 10 (25.0%) 18 (22.0%)
 > 10 years 2 (3.5%) 2 (2.7%) 4 (3.0%) 5 (11.9%) 2 (5.0%) 8 (9.8%)
Clinical variables       
Ventilation       
 Spontaneous breathing 58 (63.8%) 47 (62.7%) 85 (63.3%) 31 (73.8%) 26 (65.0%) 57 (69.5%)
 Non invasive-ventilation 13 (22.4%) 23 (30.7%) 36 (27.1%) 11 (26.2%) 14 (35.0%) 25 (30.5%)
 Tracheostomy 8 (13.8%) 5 (6.6%) 13 (9.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
 Total mechanical ventilation 21 (36.2%) 28 (37.3%) 49 (36.7%) 11 (26.2%) 14 (35.0%) 25 (30.5%)
Feeding       
 By mouth 48 (82.8%) 57 (76.0%) 105 (79.0%) 42 (100.0%) 40 (100.0%) 82 (100.0%)
 Nasogastric tube 1 (1.7%) 5 (6.7%) 6 (4.5%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
 Percutaneous endoscopic gastrostomy 9 (15.5%) 13 (17.3%) 22 (16.5%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
 Total artificial feeding 10 (17.2%) 18 (24.0%) 28 (21.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
Anthropometric variables       
Weight (kg) 7.2 (6.2; 9.1) 7.4 (6.2; 9.3) 7.4 (6.2; 9.2) 14.4 (11.5; 19.2) 13.6 (10.4; 20.0) 14.2 (10.7; 19.8)
Weight z-score (WHO) − 1.64 (− 2.39; − 0.69) − 0.72 (− 1.73; − 0.05) − 1.01 (− 2.17; − 0.12)*δ − 1.04 (− 2.26; − 0.24) − 1.06 (− 2.17; − 0.36) − 1.04 (− 2.26; − 0.33)*
Length (m) 0.72 (0.67; 0.86) 0.72 (0.66; 0.82) 0.72 (0.66; 0.84) 1.05 (0.89; 1.17) 0.97 (0.84; 1.11) 1.02 (0.87; 1.15)
Length z-score (WHO) 0.54 (− 0.28; 1.50) 1.03 (− 0.17; 1.99) 0.82 (− 0.15; 1.80) − 0.17 (− 0.78;1.20) − 0.62 (− 2.12; 0.69) 0.41 (− 1.78; 0.83)
BMI (kg/m2) 13.4 (12.1; 14.9) 13.9 (12.7; 14.9) 13.7 (12.3; 14.9) 14.1 (12.6; 15.9) 14.1 (13.2; 15.9) 14.1 (12.8; 15.9)
BMI z-score (WHO) − 2.61 (− 3.87; − 1.72) − 2.22 (− 3.19; − 1.08) − 2.48 (− 4.17; − 1.43)*δ − 1.23 (− 2.91; − 0.35) − 0.75 (− 1.93; − 0.45) − 1.28 (− 2.61; − 0.13)*
  1. Data are presented as median and interquartile range (IQR) for continuous measures, and n (%) for categorical measures
  2. BMI body mass index (Body Weight (kg)/Body Length (m2))
  3. *p < 0.050 Spontaneous breathing versus mechanical ventilation
  4. δp < 0.050 Fed by mouth versus total artificial feeding