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Table 1 Demographic, clinical and anthropometric variables in SMA1 and SMA2 children

From: Growth patterns in children with spinal muscular atrophy

 

SMA1

SMA2

Male

Female

Total

Male

Female

Total

N = 58 (43.6%)

N = 75 (56.4%)

N = 133

N = 42 (51.2%)

N = 40 (48.8%)

N = 82

Demographic variables

      

Age (years)

0.7 (0.4; 2.1)

0.6 (0.4; 1.4)

0.6 (0.4; 1.6)

4.3 (2.2; 7.0)

3.9 (1.9; 6.7)

4.1 (2.1; 6.7)

Age classes

      

 0–1 year

35 (60.3%)

51 (68.0%)

86 (64.7%)

1 (2.4%)

0 (0.0%)

1 (1.2%)

 1–3 years

14 (24.1%)

10 (13.3%)

24 (18.0%)

12 (28.6%)

15 (37.5%)

27 (32.9%)

 3–6 years

4 (6.9%)

8 (10.7%)

12 (9.0%)

15 (35.7%)

13 (32.5%)

28 (34.1%)

 6–10 years

3 (5.2%)

4 (5.3%)

7 (5.3%)

9 (21.4%)

10 (25.0%)

18 (22.0%)

 > 10 years

2 (3.5%)

2 (2.7%)

4 (3.0%)

5 (11.9%)

2 (5.0%)

8 (9.8%)

Clinical variables

      

Ventilation

      

 Spontaneous breathing

58 (63.8%)

47 (62.7%)

85 (63.3%)

31 (73.8%)

26 (65.0%)

57 (69.5%)

 Non invasive-ventilation

13 (22.4%)

23 (30.7%)

36 (27.1%)

11 (26.2%)

14 (35.0%)

25 (30.5%)

 Tracheostomy

8 (13.8%)

5 (6.6%)

13 (9.6%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

 Total mechanical ventilation

21 (36.2%)

28 (37.3%)

49 (36.7%)

11 (26.2%)

14 (35.0%)

25 (30.5%)

Feeding

      

 By mouth

48 (82.8%)

57 (76.0%)

105 (79.0%)

42 (100.0%)

40 (100.0%)

82 (100.0%)

 Nasogastric tube

1 (1.7%)

5 (6.7%)

6 (4.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

 Percutaneous endoscopic gastrostomy

9 (15.5%)

13 (17.3%)

22 (16.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

 Total artificial feeding

10 (17.2%)

18 (24.0%)

28 (21.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Anthropometric variables

      

Weight (kg)

7.2 (6.2; 9.1)

7.4 (6.2; 9.3)

7.4 (6.2; 9.2)

14.4 (11.5; 19.2)

13.6 (10.4; 20.0)

14.2 (10.7; 19.8)

Weight z-score (WHO)

− 1.64 (− 2.39; − 0.69)

− 0.72 (− 1.73; − 0.05)

− 1.01 (− 2.17; − 0.12)*δ

− 1.04 (− 2.26; − 0.24)

− 1.06 (− 2.17; − 0.36)

− 1.04 (− 2.26; − 0.33)*

Length (m)

0.72 (0.67; 0.86)

0.72 (0.66; 0.82)

0.72 (0.66; 0.84)

1.05 (0.89; 1.17)

0.97 (0.84; 1.11)

1.02 (0.87; 1.15)

Length z-score (WHO)

0.54 (− 0.28; 1.50)

1.03 (− 0.17; 1.99)

0.82 (− 0.15; 1.80)

− 0.17 (− 0.78;1.20)

− 0.62 (− 2.12; 0.69)

0.41 (− 1.78; 0.83)

BMI (kg/m2)

13.4 (12.1; 14.9)

13.9 (12.7; 14.9)

13.7 (12.3; 14.9)

14.1 (12.6; 15.9)

14.1 (13.2; 15.9)

14.1 (12.8; 15.9)

BMI z-score (WHO)

− 2.61 (− 3.87; − 1.72)

− 2.22 (− 3.19; − 1.08)

− 2.48 (− 4.17; − 1.43)*δ

− 1.23 (− 2.91; − 0.35)

− 0.75 (− 1.93; − 0.45)

− 1.28 (− 2.61; − 0.13)*

  1. Data are presented as median and interquartile range (IQR) for continuous measures, and n (%) for categorical measures
  2. BMI body mass index (Body Weight (kg)/Body Length (m2))
  3. *p < 0.050 Spontaneous breathing versus mechanical ventilation
  4. δp < 0.050 Fed by mouth versus total artificial feeding