Potential markers for sample size estimations in hereditary spastic paraplegia type 5

Table 2 Sample size estimation

	Effect size	Standard deviation of effect size	Standard effect size \|t\|	Sample size
SCA-T9	5.08 mm²	1.98 mm²	1.29	22
RL-T9	0.83 mm	0.32 mm	1.08	30
AP-T9	0.46 mm	0.23 mm	0.99	36
AP/RL-C2	− 0.06	0.04	0.69	68
CSF 27-OHC	− 1.07 ng/ml	0.92 ng/ml	0.62	86
SCA-C1	4.25 mm²	4.93 mm²	0.59	92
AP/RL-T3	0.03	0.04	0.57	100
RL-C2	0.59 mm	0.43 mm	0.56	104
RL-C1	0.53 mm	0.46 mm	0.52	118
Disability score	− 0.67	0.61	0.51	124

SCA, spinal cord area; RL, right to left diameter of spinal cord; AP, anterior to posterior diameter of spinal cord; AP/RL, AP/RL ratio; CSF, cerebrospinal fluid; 27-OHC, 27-hydroxycholesterol

ISSN: 1750-1172