Fig. 1
From: Potential markers for sample size estimations in hereditary spastic paraplegia type 5
Quantitative MRI to assess spinal cord area. A Processing included 3 steps: (1) composing the cervical and thoracic spinal cord with 3D-T2W-SPACE; (2) segmentation and labeling the spinal cord; (3) measurement of spinal cord cross-sectional area (SCA) and sectional diameter (RL and AP). B Area of spinal cords (C2-T9) in SPG5 patients and matched healthy controls, comparisons performed using Mann–Whitney test, **P < 0.01, ***P < 0.001. C, D Representative MRIs of SPG5 and healthy control. In SPG5 patients, a significant thinning in the spinal cord was observed (blue arrow) in the 3D T1-weighted and 3D T2-weighted sequence, respectively