Table 4 Linear mixed regression results

Age at enrollment (per decade)

0.11

(0.09, 0.13)

< 0.001

n/a

n/a

n/a

Year of visit

n/a

n/a

n/a

0.48

(0.31, 0.64)

< 0.001

Female

0.04

(− 0.04, 0.11)

0.348

− 0.02

(− 0.05, 0.02)

0.310

ACVRL1 (compared to Endoglin)

− 0.01

(− 0.98, 0.77)

0.812

− 0.28

(− 0.11, 0.66)

0.158

Brain VM

− 0.03

(− 0.13, 0.06)

0.506

0.00

(− 0.39, 0.38)

0.981

Pulmonary AVM

0.04

(− 0.04, 0.11)

0.361

0.00

(− 0.35, 0.34)

0.984

Liver VM

0.19

(0.09, 0.30)

< 0.001

0.16

(− 0.29, 0.60)

0.483

GI bleeding

0.37

(0.26, 0.47)

< 0.001

0.64

(0.21, 1.08)

0.004

Anemia

0.35

(0.27, 0.43)

< 0.001

0.34

(0.00, 0.68)

0.051