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Table 1 Characteristics of the 15 subjects with hypohidrotic ectodermal dysplasia (HED) investigated in this study

From: Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia

Subject Sex Age HED-related genotype Zygosity Ectodysplasin A Blood PCR test for Duration of IgG against Postinfectious
  (m/f) (years) Gene Pathogenic variant   Signalling group SARS-CoV-2 COVID-19 SARS-CoV-2 fatigue
ED-A1 m 49 EDA c.1091T > G (p.M364R) Hemizygous Abrogated A Rh +  pos. (03/2020) 22 days Yes Moderate
ED-A2 f 27 EDAR c.486delC Homozygous Abrogated B Rh +  n.d. (03/2020) 8 days Yes Severe
ED-A3 m 20 EDA c.896G > C (p.G299A) Hemizygous Abrogated 0 Rh +  pos. (11/2020) 13 days Yes None
ED-A4 m 46 EDA del exons 4–9 Hemizygous Abrogated 0 Rh +  pos. (12/2020) 23 days Yes Severe
ED-Y1 m 15 EDA c.896G > C (p.G299A) Hemizygous Abrogated 0 Rh +  pos. (10/2020) 45 days Yes Moderate
ED-Y2 m 16 EDA c.477C > T (p.R153C) Hemizygous Abrogated n.d pos. (11/2020) 12 days Yes Extreme
ED-C1 m 9 EDA c.45_49del5 Hemizygous Abrogated n.d n.d. (03/2020) no symptoms Yes None
ED-A5 f 37 EDA c.466C > T (p.R156C) heterozygous residual activity 0 Rh +  pos. (03/2020) 13 days Yes None
ED-A6 f 40 EDA c.45_49del5 Heterozygous Residual activity 0 Rh +  n.d. (03/2020) 27 days Yes None
ED-A7 f 19 EDA c.896G > C (p.G299A) Heterozygous Residual activity 0 Rh- pos. (10/2020) 3 days yes none
ED-A8 m 22 EDA c.769G > C (p.G257R) Hemizygous Residual activity 0 Rh- pos. (10/2020) 7 days Yes None
ED-A9 f 42 EDA c.896G > C (p.G299A) Heterozygous Residual activity 0 Rh- pos. (10/2020) 21 days Yes Mild
ED-A10 f 46 EDA c.477C > T (p.R153C) Heterozygous Residual activity A Rh +  pos. (11/2020) 4 days Yes None
ED-A11 f 52 EDA c.896G > C (p.G299A) Heterozygous Residual activity 0 Rh +  pos. (11/2020) 20 days Yes Moderate
ED-Y3 f 16 EDA c.1091T > G (p.M364R) Heterozygous Residual activity A Rh +  pos. (03/2020) 7 days Yes None
  1. Bold highlights the only patient without clinical symptoms
  2. m, male; f, female; n.d., not determined; pos., positive test result