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Table 1 Characteristics of the 15 subjects with hypohidrotic ectodermal dysplasia (HED) investigated in this study

From: Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia

Subject

Sex

Age

HED-related genotype

Zygosity

Ectodysplasin A

Blood

PCR test for

Duration of

IgG against

Postinfectious

 

(m/f)

(years)

Gene

Pathogenic variant

 

Signalling

group

SARS-CoV-2

COVID-19

SARS-CoV-2

fatigue

ED-A1

m

49

EDA

c.1091T > G (p.M364R)

Hemizygous

Abrogated

A Rh + 

pos. (03/2020)

22 days

Yes

Moderate

ED-A2

f

27

EDAR

c.486delC

Homozygous

Abrogated

B Rh + 

n.d. (03/2020)

8 days

Yes

Severe

ED-A3

m

20

EDA

c.896G > C (p.G299A)

Hemizygous

Abrogated

0 Rh + 

pos. (11/2020)

13 days

Yes

None

ED-A4

m

46

EDA

del exons 4–9

Hemizygous

Abrogated

0 Rh + 

pos. (12/2020)

23 days

Yes

Severe

ED-Y1

m

15

EDA

c.896G > C (p.G299A)

Hemizygous

Abrogated

0 Rh + 

pos. (10/2020)

45 days

Yes

Moderate

ED-Y2

m

16

EDA

c.477C > T (p.R153C)

Hemizygous

Abrogated

n.d

pos. (11/2020)

12 days

Yes

Extreme

ED-C1

m

9

EDA

c.45_49del5

Hemizygous

Abrogated

n.d

n.d. (03/2020)

no symptoms

Yes

None

ED-A5

f

37

EDA

c.466C > T (p.R156C)

heterozygous

residual activity

0 Rh + 

pos. (03/2020)

13 days

Yes

None

ED-A6

f

40

EDA

c.45_49del5

Heterozygous

Residual activity

0 Rh + 

n.d. (03/2020)

27 days

Yes

None

ED-A7

f

19

EDA

c.896G > C (p.G299A)

Heterozygous

Residual activity

0 Rh-

pos. (10/2020)

3 days

yes

none

ED-A8

m

22

EDA

c.769G > C (p.G257R)

Hemizygous

Residual activity

0 Rh-

pos. (10/2020)

7 days

Yes

None

ED-A9

f

42

EDA

c.896G > C (p.G299A)

Heterozygous

Residual activity

0 Rh-

pos. (10/2020)

21 days

Yes

Mild

ED-A10

f

46

EDA

c.477C > T (p.R153C)

Heterozygous

Residual activity

A Rh + 

pos. (11/2020)

4 days

Yes

None

ED-A11

f

52

EDA

c.896G > C (p.G299A)

Heterozygous

Residual activity

0 Rh + 

pos. (11/2020)

20 days

Yes

Moderate

ED-Y3

f

16

EDA

c.1091T > G (p.M364R)

Heterozygous

Residual activity

A Rh + 

pos. (03/2020)

7 days

Yes

None

  1. Bold highlights the only patient without clinical symptoms
  2. m, male; f, female; n.d., not determined; pos., positive test result