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Table 2 Characteristics of cannabinoid-based medicines

From: Cannabinoid use and effects in patients with epidermolysis bullosa: an international cross-sectional survey study

Survey item subject (number of responses to item)

Multiple choice options for survey responses

All respondents (%)

Respondents < 13 years (%)

CBM type*

 N all respondents = 60

 N < 13y = 19

Oil/paste

46 (76.7)

11 (57.9)

Dried flower/Flos

33 (55.0)

2 (10.5)

Edible

29 (48.3)

2 (10.5)

Tincture

17 (28.3)

3 (15.8)

Other liquid form

11 (18.3)

1 (5.3)

Pill

5 (8.3)

–

Total CBM types used

141

19

Mean per participant

2.4 (± 1.5)

1.0 (± 0.7)

CBM route of administration*

 N all respondents = 60

 N < 13y = 19

Topical

36 (60.0)

12 (63.2)

Ingested

36 (60.0)

4 (21.1)

Inhaled

33 (55.0)

–

Sublingual

23 (38.3)

4 (21.1)

Total routes reported

128

20

Mean per participant

2.1 (± 1.1)

1.1 (± 0.8)

Topical CBM type*

 N all respondents = 36

 N < 13y = 19

Cream

24 (66.7)

8 (42.1)

Oil

23 (63.9)

6 (31.6)

Lotion

12 (33.3)

4 (21.1)

Spray

3 (8.3)

1 (5.3)

Foam

–

–

Total types of topicals

62

19

Mean per participant

1.7 (± 1.1)

1.1 (± 1.2)

Composition of CBM (THC vs. CBD)*

 N All Respondents = 58

 N < 13y = 19

THC only

18 (15.3)

–

THC/CBD combination

41 (34.7)

6 (31.6)

CBD only

24 (20.3)

9 (47.4)

Unknown

35 (29.7)

4 (21.1)

Total compositions reported

118

19

Current frequency of CBM administration

 N all respondents = 51

 N < 13y = 10

Less than once per week

5 (9.8)

2 (20.0)

Once per week

2 (3.9)

–

Several times per week

8 (15.7)

1 (10.0)

Once per day

15 (29.4)

4 (40.0)

Several times per day

19 (37.3)

2 (20.0)

Unsure

2 (3.9)

1 (10.0)

Change over time: dose of CBM

 N all respondents = 52

 N < 13y = 11

Dose decreased

6 (11.5)

1 (9.1)

Dose remained stable

13 (25.0)

2 (18.2)

Dose increased

13 (25.0)

4 (36.4)

Dose fluctuated

17 (32.7)

2 (18.2)

Unsure

3 (5.8)

2 (18.2)

Change over time: frequency of CBM administration

 N all respondents = 52

 N < 13y = 11

Administered less frequently

7 (13.5)

1 (9.1)

Frequency remained stable

17 (32.7)

3 (27.3)

Administered more frequently

9 (17.3)

2 (18.2)

Administration frequency fluctuated

17 (32.7)

4 (36.4)

Unsure

2 (3.8)

1

CBM source of acquisition*

 N All Respondents = 50

 N < 13y = 10

Cannabis dispensary

31 (62.0)

6 (60.0)

Social connection

19 (38.0)

2 (20.0)

Internet web-shops

6 (12.0)

4 (40.0)

Medical pharmacy

5 (10.0)

1 (10.0)

Cultivated at home

4 (8.0)

–

Prefer not to answer

1 (2.0)

–

Total number of sources

66 (100)

13 (100)

Preferred route of administration

 N all respondents = 44

 N < 13y = 9

Topical

11 (25.0)

4 (44.4)

Inhaled

18 (40.9)

 

Ingested

10 (22.7)

2 (22.2)

Sublingual

5 (11.4)

3 (33.3)

Duration of use

 N all respondents = 52

 N < 13y = 11

 < 6 months

6 months–1 year

1–5 years

 > 5 years

13 (25.0)

7 (13.5)

18 (34.6)

14 (26.9)

5 (45.5)

4 (36.4)

2 (18.2)

–

Reported side effects*

 N all respondents = 45

 N < 13y = 9

Dry mouth

20 (44.4)

–

Cough/wheezing

13 (28.8)

–

Dry/red eyes

12 (26.7)

1 (11.1)

Fatigue

10 (22.2)

–

Dizziness

7 (15.6)

–

Paranoia

3 (6.7)

–

Problems with memory/attention

3 (6.7)

–

Problems with coordination

3 (6.7)

–

CBM prescribed by physician

 N all respondents = 50

 N < 13y = 10

Yes

12 (24.0)

1 (10.0)

No

38 (76.0)

9 (90.0)

Physician aware of CBM use

 N all respondents = 50

 N < 13y = 9

Yes

28 (73.7)

7 (77.8)

No

10 (26.3)

2 (22.2)

  1. Reported cannabinoid-based medicines (CBMs) and characteristics of administration in the total cohort. * Indicates that participants were able to select more than one response. Participants were not required to respond to each item. Administration by way of suppositories were not reported by any participant
  2. THC: delta-9-tetrahydrocannabinol, CBD: cannabidiol