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Table 4 Linear regression of biomarkers levels associated with HHT-related phenotypes

From: Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations

Marker

BAVM

PAVM

LVM

GI bleeding

PI

95% CI

p value

q-value

PI

95% CI

p value

q-value

PI

95% CI

p value

q-value

PI

95% CI

p value

q-value

ANG2

1.18

(0.48, 2.91)

0.725

1

1.56

(0.59, 4.16)

0.371

1

0.43

(0.08, 2.30)

0.325

1

0.61

(0.20, 1.80)

0.368

1

BMP9

2.20

(0.66, 7.30)

0.197

1

0.64

(0.17, 2.35)

0.501

1

0.49

(0.05, 4.41)

0.522

1

1.87

(0.46, 7.54)

0.381

1

sCD73

1.11

(0.70, 1.76)

0.646

1

0.75

(0.45, 1.24)

0.256

1

0.79

(0.32, 1.99)

0.623

1

1.54

(0.89, 2.69)

0.125

1

sENG

0.76

(0.58, 1.00)

0.050

0.646

0.76

(0.56, 1.04)

0.084

1

2.07

(1.35, 3.18)

0.001

0.028

1.06

(0.75, 1.51)

0.725

1

GP130

0.78

(0.68, 0.89)

< 0.001

0.017

1.01

(0.85, 1.20)

0.930

1

1.65

(1.30, 2.09)

< 0.001

0.002

0.86

(0.72, 1.04)

0.112

1

HGF

1.26

(0.51, 3.13)

0.620

1

1.72

(0.64, 4.57)

0.280

1

0.24

(0.04, 1.35)

0.105

1

0.73

(0.24, 2.20)

0.575

1

sICAM1

0.74

(0.62, 0.88)

0.001

0.017

0.95

(0.77, 1.18)

0.648

1

1.50

(1.13, 1.98)

0.004

0.080

1.08

(0.85, 1.37)

0.516

1

IL6

1.13

(0.64, 1.98)

0.679

1

0.67

(0.35, 1.26)

0.209

1

0.64

(0.20, 2.05)

0.452

1

1.46

(0.73, 2.89)

0.283

1

sIL6R

0.88

(0.73, 1.08)

0.221

1

1.04

(0.84, 1.28)

0.750

1

1.27

(0.88, 1.83)

0.203

1

0.80

(0.64, 0.99)

0.043

1

OPN

1.05

(0.77, 1.43)

0.762

1

1.01

(0.73, 1.40)

0.962

1

0.75

(0.42, 1.34)

0.335

1

1.21

(0.86, 1.72)

0.278

1

PDGF-AA

0.55

(0.28, 1.07)

0.077

0.873

1.32

(0.63, 2.75)

0.458

1

3.83

(1.35, 10.87)

0.012

0.175

0.59

(0.27, 1.28)

0.181

1

PDGF-BB

0.93

(0.54, 1.60)

0.801

1

1.22

(0.68, 2.20)

0.503

1

0.93

(0.36, 2.42)

0.884

1

0.76

(0.39, 1.45)

0.404

1

PIGF

1.09

(0.86, 1.38)

0.480

1

1.26

(0.98, 1.61)

0.073

1

0.66

(0.42, 1.02)

0.062

0.805

1.05

(0.78, 1.40)

0.758

1

SDF1

0.93

(0.70, 1.24)

0.618

1

0.96

(0.69, 1.33)

0.786

1

0.83

(0.47, 1.45)

0.514

1

0.98

(0.68, 1.40)

0.902

1

TGFβ1

0.90

(0.63, 1.27)

0.546

1

0.96

(0.66, 1.40)

0.837

1

1.46

(0.77, 2.77)

0.241

1

1.12

(0.75, 1.67)

0.596

1

TGFβ2

0.98

(0.72, 1.34)

0.917

1

1.10

(0.79, 1.53)

0.574

1

1.20

(0.68, 2.11)

0.526

1

1.06

(0.74, 1.52)

0.756

1

sTGFβR3

0.86

(0.66, 1.11)

0.242

1

1.09

(0.82, 1.44)

0.560

1

1.12

(0.74, 1.69)

0.584

1

1.10

(0.82, 1.48)

0.536

1

TIMP1

0.74

(0.58, 0.94)

0.015

0.225

0.93

(0.70, 1.23)

0.607

1

1.94

(1.29, 2.92)

0.002

0.034

0.99

(0.73, 1.34)

0.923

1

TSP2

0.59

(0.44, 0.80)

0.001

0.017

1.04

(0.71, 1.52)

0.831

1

3.39

(2.08, 5.53)

< 0.001

< 0.001

0.83

(0.55, 1.24)

0.360

1

sVCAM1

0.87

(0.71, 1.06)

0.161

1

1.13

(0.91, 1.41)

0.265

1

1.29

(0.90, 1.86)

0.165

1

0.96

(0.76, 1.22)

0.749

1

VEGF

0.68

(0.38, 1.21)

0.192

1

0.97

(0.51, 1.85)

0.931

1

2.02

(0.64, 6.37)

0.228

1

1.42

(0.70, 2.88)

0.334

1

sVEGFR1

1.73

(0.65, 4.62)

0.271

1

1.23

(0.39, 3.82)

0.726

1

0.24

(0.03, 1.87)

0.173

1

0.56

(0.17, 1.87)

0.343

1

sVEGFR2

0.77

(0.63, 0.94)

0.011

0.199

1.06

(0.83, 1.36)

0.651

1

1.12

(0.72, 1.74)

0.603

1

0.93

(0.71, 1.22)

0.600

1

sVEGFR3

0.75

(0.63, 0.88)

0.001

0.017

0.99

(0.81, 1.22)

0.942

1

1.31

(0.94, 1.82)

0.110

1

0.96

(0.77, 1.20)

0.720

1

  1. CI confidence interval; PI proportional increase
  2. Bold values indicate markers with a q-value less than 0.05. Sample sizes vary from 33 to 42 for BAVM, PAVM, and GI bleeding, and 28 to 37 for LVM
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172