| Age (procedure) | H&E staining | TEM assessment |
---|---|---|---|
Patient 1 | 11 months (endoscopy) | Rectum: active and chronic inflammation; cryptitis; 10 ± EOS/HPF | ND |
26Â months (endoscopy) | Colon: chronic inflammation; tufts or teardrop appearance; eosinophils and plasma cells infiltration | ND | |
27Â months (surgery) | Stomach: chronic gastritis; submucosal edema, hyperemia Jejunum: villous blunting; tufts at villus tips; lymphocyte infiltration in the epithelial layer; prominent inflammatory cell infiltration in lamina propria Ileum: focal mucosal erosion and hyperemia; lymphocyte infiltration; tufts at villus tips Colon: tufts or teardrop appearance; hyperemia; edema | Jejunum: focal loss of microvilli and disorganized cellular junctions; Colon: focal loss of microvilli | |
31Â months (endoscopy) | Stomach: chronic gastritis Ileum: chronic inflammation; tufts at villus tips | ND | |
34Â months (surgery) | Colon: mucosal hyperemia, edema, and erosion; tufts or teardrop appearance | ND | |
40Â months (surgery and endoscopy) | Ileum: villous blunting or missing; tufts at villus tips; submucosal lymphoid hyperplasia Colon: chronic mucosal inflammation; tufts or teardrop appearance; inflammatory cell infiltration in lamina propria | ND | |
Patient 2 | 43Â days (endoscopy) | Duodenum: villous atrophy; disorganized epithelium Ileum: villous atrophy; crowded epithelial cells Colon: chronic inflammation; villous atrophy | Ileum: flattened microvilli; swollen epithelial cells and slightly dilated endoplasmic reticulum; interstitial edema; infiltration of lymphocytes and plasma cells |
Patient 3 | 4Â days (surgery) | Ileum: hyperemia, edema, and lymphocyte aggregates; a proliferation of submucosal fibrous tissue Colon: hyperemia, edema, and lymphocyte aggregates; a proliferation of submucosal fibrous tissue | ND |
Patient 4 | 71Â days (endoscopy) | Duodenum: hyperemia, edema, and prominent lymphocyte infiltration; villous blunting Ileum: hyperemia, edema, and prominent lymphoid aggregates; villous blunting | Ileum: focal loss of microvilli; swollen epithelial cells; infiltration of interstitial plasma cells, lymphocytes, and eosinophils |