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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Monogenic mutations in four cases of neonatal-onset watery diarrhea and a mutation review in East Asia

Fig. 2

H&E staining of intestinal biopsy from Patient 1. A Chronic inflammation; tufts or teardrop appearance; infiltration of eosinophils and plasma cells in the colon at 26 months (200×). B Atrophic villi with crowded epithelial cells forming tufts in the jejunum biopsy at 27 months (200×). C Villus shortening, disorganized proliferating epithelial cells, focal tufting, and crypt hyperplasia in the ileum biopsy at 27 months (200×). D Tufts or teardrop appearance and crypt hyperplasia in the colon at 27 months (200×). E Villous blunting; tufts at villus tips in the ileum near the stoma at 40 months (200×). F Chronic mucosal inflammation; tufts or teardrop appearance; inflammatory cell infiltration in the lamina propria of the colon at 40 months (200×)

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