Hospital mortality in patients with rare diseases during pandemics: lessons learnt from the COVID-19 and SARS pandemics

Table 4 Logistic regression model on the association between different variables and the odds of hospital mortality before and during the SARS pandemic

Factors	Crude OR	95% C.I.	p value	Adjusted OR^a	Adjusted 95% C.I.^a	Adjusted p value^a
Rare disease
No (general population)	1.00	–	–	1.00	–	–
Yes	2.32	2.18–2.46	< 0.001	2.91	2.73–3.09	< 0.001
Age
≤ 18	1.00	–	–	1.00	–	–
19–59	4.99	4.34–5.74	< 0.001	5.20	4.52–5.98	< 0.001
≥ 60	31.29	27.30–35.87	< 0.001	33.51	29.22–38.41	< 0.001
Time period
Admitted one year before pandemic (2002)	1.00	–	–	1.00	–	–
Admitted with SARS infection during pandemic period (2003)	4.78	4.16–5.50	< 0.001	8.10	6.96–9.42	< 0.001
Admitted without SARS infection during pandemic period (2003)	1.57	1.53–1.62	< 0.001	1.60	1.55–1.64	< 0.001

C.I. confidence interval, OR odds ratio, SARS severe acute respiratory syndrome
^aAdjusted for each and all of the variables in the table

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