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Table 3 Pharmokinetic parameters

From: A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis

Parameter IR-cysteamine (Cystagon®) DR-cysteamine (Procysbi®) p-value
Mean minimum concentration of cystine (in nmol cystine/mg protein) 0.38 ± 0.3 0.41 ± 0.41 0.59
Mean Cmax of cysteamine (in µmol/l) 72.58 ± 46.45 56.2 ± 28.3 0.28
Mean Tmax of cysteamine (in minutes) 75.0 ± 24.5 159.38 ± 39.07 0.001
Time with cystine values under 0.5 (in minutes) 196.46 216.71 0.55
AUC cysteamine (after 1 dosing) 9400.8 11,578.8  
AUC cysteamine (24 h) 37,603.2 23,157.6  
  1. This table shows mean values incl. standard deviations and p-values of pharmacokinetic parameters of 17 patients after ingestion of a single dose of IR-cysteamine (Cystagon®), DR-cysteamine (Procysbi®) respectively