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Table 4 Factors associated with shorter time from disease onset to loss of autonomy

From: Natural history of Lafora disease: a prognostic systematic review and individual participant data meta-analysis

Phenotypic characteristic variable versus reference category Unadjusted HR (95% CI) P-value Adjusted HR (95% CI) P-value
Geographic origin     
Asian vs European 2.5 (0.9–7.0) 0.071 4.1 (1.4–12.7) 0.013
African vs European 7.4 (0.3–180) 0.222 7.4 (0.2–284) 0.28
American vs European 1.8 (0.7–4.7) 0.20 2.3 (0.8–6.8) 0.13
Sex     
Male versus female 1.0 (0.4–2.8) 0.95   
Age at onset     
 ≥ 18 versus < 18 years 0.48 (0.24–0.96) 0.039 0.18 (0.04–0.79) 0.024
Consanguinity     
Present versus Absent 1.2 (0.5–2.5) 0.71   
Mutated gene     
EPM2B versus EPM2A 2.7 (0.9–8.6) 0.084 1.6 (0.4–7.4) 0.53
Compound heterozygosity     
Present versus absent 0.8 (0.4–1.6) 0.52   
Type of onset     
Motor versus Epileptic 0.9 (0.3–3.1) 0.93 0.9 (0.3–3.0) 0.82
Cognitive versus Epileptic 0.5 (0.2–1.6) 0.26 0.7 (0.2–2.0) 0.49
  1. Bold means statistically significant value (P < 0.005)