Fig. 1

Medical history of a 55-year woman with a metastatic malignant phyllodes tumor (MPT). The patient from Kazakhstan was initially diagnosed with an invasive sarcoma, which was later identified as a MPT following review in the Breast Unit of the Kliniken Essen-Mitte (KEM). In 2009, she had undergone adnexectomy due to the presence of an ovarian cyst. During her examination at the KEM, several pulmonary nodules were detected. Excision and histological characterization of the nodules revealed distant metastases of the MPT. The patient received several lines of chemotherapy treatment and the angiogenesis inhibitor bevacizumab. After her last appointment at the KEM in 06/2019, the patient was lost to follow-up. Next-generation sequencing (NGS) of the metastatic and primary tumor samples was performed