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Table 1 Prevalence of ASD, ADHD and ID in the TS 2000 and TOSCA studies

From: A comparison of two studies and the prevalence and sex ratio of Neurodevelopmental conditions in Tuberous Sclerosis Complex

  TS 2000—prevalence TOSCA—prevalence Chi-squared analysis
Definite ASDa 43% (n = 80) 21% (n = 1486) \({ X}^{2}\)(1) = 18.84***
Probable ASDb 68% (n = 80) \({X}^{2}\)(1) = 88.23***
Definite ADHDc 23% (n = 78) 19% (n = 1404) \({ X}^{2}\)(1) = 0.52
Probable ADHDd 46% (n = 78) \({ X}^{2}\)(1) = 31.56***
Normal IQ
(70+)
43% (n = 88) 44% (n = 885) \({ X}^{2}\)(1) = 0.01
Mild-to-moderate intellectual disability (35–70) 45% (n = 88) 43% (n = 885) \({ X}^{2}\)(1) = 0.09
Severe-to-profound intellectual disability (0–34) 11% (n = 88) 12% (n = 885) \({X }^{2}\)(1) = 0.01
  1. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001
  2. aADI-R and ADOS-2 positive
  3. bADI-R or ADOS-2 positive
  4. cPervasive and persistent ADHD
  5. dPervasive or persistent ADHD